A 77-01
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- CAS号:
- 607737-87-1
- 英文名:
- 4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE
- 英文别名:
- A77-01;A-77-01;A 77-01;CS-1775;A7701;A 7701; A-7701;4-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline;4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE;4-[5-(6-methylpyridin-2-yl)-1~{H}-pyrazol-4-yl]quinoline;Quinoline, 4-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-;TGF-β Receptor,Transforming growth factor beta receptors,A 77-01,Inhibitor,A 77 01,inhibit,A 7701
- 中文名:
- A 77-01
- 中文别名:
- 化合物A77-01;TGF-Β I型受体家族ALK5抑制剂(A 77-01);4-(3-(6-甲基吡啶-2-基)-1H-吡唑-4-基)喹啉;4-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]喹啉
- CBNumber:
- CB6727914
- 分子式:
- C18H14N4
- 分子量:
- 286.33
- MOL File:
- 607737-87-1.mol
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A 77-01化学性质
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储存条件:
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Store at -20°C
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溶解度:
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insoluble in H2O; ≥14.3 mg/mL in DMSO; ≥8.84 mg/mL in EtOH with gentle warming and ultrasonic
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形态:
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solid
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A 77-01性质、用途与生产工艺
A 77-01 是一种有效的 TGF-β I 型受体家族 ALK5 抑制剂，IC50 值为 25 nM。
A-77-01 (0.01-10 µM; 25 hours; Mv1Lu cells) treatment effectively inhibits TGF-β-induced transcriptional activation in concentration-dependent fashion.
A-77-01 (1 µM; 24-72 hours; Mv1Lu cells) treatment efficiently prevents the growth-inhibitory effects of TGF-β.
A-77-01 (1 µM; 30 minutes; HaCaT cells) treatment inhibits TGF-β-induced phosphorylation of Smad2.
RT-PCR
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Cell Line:
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Mv1Lu cells
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Concentration:
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0.01 µM, 0.03 µM, 0.1 µM, 0.3 µM, 1 µM, 3 µM, 10 µM
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Incubation Time:
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25 hours
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Result:
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Inhibited the luciferase activity induced by TGF-β in concentration-dependent fashion.
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Cell Viability Assay
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Cell Line:
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Mv1Lu cells
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Concentration:
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1 µM
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Incubation Time:
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24 hours, 48 hours, 72 hours
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Result:
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Efficiently prevented the growth-inhibitory effects of TGF-β.
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Western Blot Analysis
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Cell Line:
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HaCaT cells
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Concentration:
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1 µM
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Incubation Time:
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30 minutes
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Result:
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Inhibited TGF-β-induced phosphorylation of Smad2.
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A 77-01
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-78349 | A 77-01 | | 1 mg | 548元 |
| 2024/04/30 | HY-78349 | A 77-01
A 77-01 | 607737-87-1 | 5mg | 1200元 |
607737-87-1, A 77-01 相关搜索:
- Inhibitors
- 酶
- 细胞生物学试剂
- 抑制剂
- 小分子抑制剂
- 小分子抑制剂，天然产物
- 4-(3-(6-甲基吡啶-2-基)-1H-吡唑-4-基)喹啉
- 化合物A77-01
- TGF-Β I型受体家族ALK5抑制剂(A 77-01)
- 4-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]喹啉
- 607737-87-1
- TGF-β Receptor,Transforming growth factor beta receptors,A 77-01,Inhibitor,A 77 01,inhibit,A 7701
- Quinoline, 4-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
- A7701;A 7701; A-7701
- 4-[5-(6-methylpyridin-2-yl)-1~{H}-pyrazol-4-yl]quinoline
- CS-1775
- 4-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline
- 4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline A 77-01
- A77-01
- A-77-01
- A 77-01
- 4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE