BMS-5
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- CAS号:
- 1338247-35-0
- 英文名:
- N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide
- 英文别名:
- LIMKI-3;CS-2190;BMS 5;BMS5;BMS-5 ≥95%;BMS-5, LIMKI-3;LIMKI-3;BMS5;BMS 5;LIMKI3;LIMKI 3;LIMKi3,inhibit,LIM Kinase (LIMK),LIMKs,Inhibitor,BMS 5,BMS-5,LIMKi-3;N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide;N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramide[BMS5;N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methylpropanamide
- 中文名:
- BMS-5
- 中文别名:
- 化合物BMS5;BMS-5游离态;LIMKI 3,LIM激酶抑制剂;N-(5-(1-(2,6-二氯苯基)-3-(二氟甲基)-1H-吡唑-5-基)噻唑-2-基)异丁酰胺
- CBNumber:
- CB72598623
- 分子式:
- C17H14Cl2F2N4OS
- 分子量:
- 431.29
- MOL File:
- 1338247-35-0.mol
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BMS-5化学性质
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密度:
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1.54±0.1 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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DMSO:PBS (pH 7.2) (1:5):0.2(Max Conc. mg/mL);0.46(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);6.96(Max Conc. mM)-
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酸度系数(pKa):
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9.51±0.50(Predicted)
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形态:
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White powder.
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BMS-5性质、用途与生产工艺
BMS-5 (LIMKi 3) 是一种有效的 LIM kinases (LIMK) 的抑制剂,对LIMK1和LIMK2的IC50值分别为7 nM和8 nM。
Target | Value |
LIMK1
(Cell-free assay)
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7 nM
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LIMK2
(Cell-free assay)
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8 nM
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BMS-5 (LIMKi 3) inhibits cofilin-Ser3 phosphorylation in a dose-dependent manner in
Nf2
ΔEx2
mouse Schwann cells (MSCs) with an IC
50
of ~2 µM. BMS-5 (LIMKi 3) reduces
Nf2
ΔEx2
MSC viability in a dose-dependent manner with an IC
50
of 3.9 µM, but does not significantly reduce the viability of control
Nf2
flox2/flox2
MSCs at equivalent BMS-5 concentrations. At 10 µM BMS-5,
Nf2
ΔEx2
MSC viability is 40% compared to 83% for controls.
BMS-5 (LIMKi 3) (20 or 200 μM/side) is bilaterally infused into the hippocampus of rats immediately after contextual fear conditioning training. Rats are tested for memory consolidation 48 h after fear conditioning. Post hoc analysis shows that the group treated with 200 μM BMS-5 express lower freezing levels compared to the 20 μM and vehicle groups (P<0.01).
BMS-5
上下游产品信息
上游原料
下游产品
1338247-35-0, BMS-5 相关搜索:
- 合成有机化合物配体
- 抑制剂
- C17H14Cl2F2N4OS
- LIMKI 3,LIM激酶抑制剂
- N-(5-(1-(2,6-二氯苯基)-3-(二氟甲基)-1H-吡唑-5-基)噻唑-2-基)异丁酰胺
- 化合物BMS5
- BMS-5游离态
- 1338247-35-0
- LIMKi3,inhibit,LIM Kinase (LIMK),LIMKs,Inhibitor,BMS 5,BMS-5,LIMKi-3
- N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramide[BMS5
- Propanamide, N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methyl-
- LIMKI-3;BMS5;BMS 5;LIMKI3;LIMKI 3
- N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methylpropanamide
- N-{5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]- 1,3-thiazol-2-yl}-2-methylpropanamide
- BMS 5;BMS5
- BMS-5 ≥95%
- CS-2190
- BMS-5, LIMKI-3
- Mitoquinone mesylateN-{5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]- 1,3-thiazol-2-yl}-2-methylpropanamide
- LIMKI-3
- N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide