苦参醇C
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- CAS号:
- 99119-73-0
- 英文名:
- Kushenol C
- 英文别名:
- Kushenol C;2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-
- 中文名:
- 苦参醇C
- 中文别名:
- 苦参醇C;苦参新醇 C
- CBNumber:
- CB73037365
- 分子式:
- C25H26O7
- 分子量:
- 438.47
- MOL File:
- 99119-73-0.mol
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苦参醇C化学性质
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溶解度:
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Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
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形态:
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powder
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颜色:
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Yellow
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苦参醇C性质、用途与生产工艺
Kushenol C 是从苦参根中分离出来的，具有抗炎和抗氧化的作用。Kushenol C 抑制 BACE1 的 IC50 值为 5.45 µM。
Kushenol C dose-dependently suppresses the production of inflammatory mediators, including NO, PGE2, IL-6, IL1β, MCP-1, and IFN-β in LPS-stimulated RAW264.7 macrophages. Kushenol C (50-100 µM;) significantly decreases the phosphorylation of both STAT1 molecules and STAT6 in a dose-dependent manner in LPS-stimulated RAW264.7 cells.
Kushenol C upregulates the expression of HO-1 and its activities in the LPS-stimulated RAW264.7 macrophages. In HaCaT cells, Kushenol C prevents DNA damage and cell death by upregulating the endogenous antioxidant defense system involving glutathione, superoxide dismutase, and catalase, which prevents reactive oxygen species production from tert-butyl hydroperoxide (tBHP)-induced oxidative stress in HaCaT cells.
Kushenol C inhibits BChE and AChE with IC
50
s of 54.86 and 33.13 µM.
苦参醇C
上下游产品信息
上游原料
下游产品
99119-73-0, 苦参醇C 相关搜索:
- 标准品
- 标准品 -中药标准品
- 中药对照品
- 苦参新醇 C
- 苦参醇C
- 99119-73-0
- 4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-
- 2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one
- Kushenol C