羟基鱼藤素
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- CAS号:
- 76-80-2
- 英文名:
- (-)-TEPHROSIN
- 英文别名:
- Deguelinol I;Isotephrosin;(-)-TEPHROSIN;Hydroxydeguelin;Tephrosin (synthetic);(-)-TEPHROSIN USP/EP/BP;Tephrosin >=95% (LC/MS-ELSD);13,13a-Dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one;3H-Bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7- (7aH)-one,13,13a-dihydro-7a-hydroxy-9,10- dimethoxy-3,3-dimethyl-,(7aR,13aR)-
- 中文名:
- 羟基鱼藤素
- 中文别名:
- 灰叶素;羟基鱼藤素/灰叶草素;化合物 T13126;灰叶草素, 羟基鱼藤素
- CBNumber:
- CB81484766
- 分子式:
- C23H22O7
- 分子量:
- 410.42
- MOL File:
- 76-80-2.mol
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羟基鱼藤素化学性质
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熔点:
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198° (218-220°)
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沸点:
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450.42°C (rough estimate)
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密度:
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1.2284 (rough estimate)
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折射率:
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1.5300 (estimate)
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储存条件:
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-20°C
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溶解度:
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Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
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形态:
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Cryst.
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酸度系数(pKa):
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10.47±0.40(Predicted)
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羟基鱼藤素性质、用途与生产工艺
Tephrosin 是一种天然类胡萝卜素，具有较强的抗肿瘤活性。Tephrosin 通过诱导受体内化来诱导 EGFR 和 ErbB2 的降解。
Treatment of HT-29 cells with tephrosin (0-10μM) inhibits both the ligand-induced and constitutive phosphorylation of EGFR, ErbB2 and ErbB3, and concomitantly suppresses the activation of the downstream signaling molecules such as Akt and Erk1/2 mitogen-activated protein kinase (MAPK) .
羟基鱼藤素
上下游产品信息
上游原料
下游产品
76-80-2, 羟基鱼藤素 相关搜索:
- Miscellaneous Natural Products
- 黄酮
- 标准品 -对照药材
- 植物提取物
- 标准品
- 羟基鱼藤素/灰叶草素
- 化合物 T13126
- 灰叶素
- 灰叶草素, 羟基鱼藤素
- 76-80-2
- (-)-TEPHROSIN
- (-)-TEPHROSIN USP/EP/BP
- Tephrosin >=95% (LC/MS-ELSD)
- 3H-Bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7- (7aH)-one,13,13a-dihydro-7a-hydroxy-9,10- dimethoxy-3,3-dimethyl-,(7aR,13aR)-
- Tephrosin (synthetic)
- Deguelinol I
- Isotephrosin
- Hydroxydeguelin
- 13,13a-Dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one