FIPI
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- CAS号:
- 939055-18-2
- 英文名:
- FIPI
- 英文别名:
- FIPI;CS-1511;Vitamin B5 Monomer;FIPI HYDROCHLORIDE;5-Fluoro-2-Indolyl des-Chlorohalopemide; 5-fluoro-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1H-indole-2-carboxamide;N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide;1H-Indole-2-carboxamide, N-[2-[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-;N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride
- 中文名:
- FIPI
- 中文别名:
- FIPI游离;化合物FIPI;5-氟-2-吲哚基脱氯卤培米特
- CBNumber:
- CB82550798
- 分子式:
- C23H24FN5O2
- 分子量:
- 421.47
- MOL File:
- 939055-18-2.mol
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FIPI化学性质
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密度:
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1.349±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 14.67 mg/mL (34.81 mM; Need ultrasonic and warming)
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形态:
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Powder
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酸度系数(pKa):
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12.04±0.30(Predicted)
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FIPI性质、用途与生产工艺
FIPI (5-Fluoro-2-indolyl deschlorohalopemide) 是一种卤培米特 (halopemide)的衍生物，是一种有效且选择性的 phospholipase D 抑制剂，对 PLD1 和 PLD2 的IC50值分别为25 nM和20 nM。
| Target | Value |
PLD2
(Cell-free assay)
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20 nM
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PLD1
(Cell-free assay)
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25 nM
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Despite the high clearance of greater than 2 L/h/kg, FIPI shows a half-life of greater than 5 h, a Cmax of greater than 10-fold the
50
versus PLD2, and moderate bioavailability of 18%. FIPI inhibits both PLD1 and PLD2 in a dose-dependent manner, with 50% loss of activity observed at approximately 25 nM. FIPI is not an irreversible suicide inhibitor but neither is it rapidly and completely reverses upon removal of the drug. IPI does not alter PLD subcellular localization, access to PIP2, actin stress fibers, or upstream signaling events. FIPI rescues PLD2-suppressed membrane ruffling and cell spreading. FIPI attenuats the thimerosal-induced PLD activation, and the Hg-induced PLD activation in MAECs in a dose-dependent manner, and the agonist- and oxidant-induced PLD activation in a dose-dependent manner in MAECs.
FIPI
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-12807 | FIPI
FIPI | 939055-18-2 | 5mg | 850元 |
| 2024/04/30 | HY-12807 | FIPI
FIPI | 939055-18-2 | 10mM * 1mLin DMSO | 935元 |
939055-18-2, FIPI 相关搜索:
- 合成有机化合物配体
- 抑制剂
- FIPI游离
- 化合物FIPI
- 5-氟-2-吲哚基脱氯卤培米特
- 939055-18-2
- Vitamin B5 Monomer
- 1H-Indole-2-carboxamide, N-[2-[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-
- 5-fluoro-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1H-indole-2-carboxamide
- CS-1511
- N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride
- N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide
- 5-Fluoro-2-Indolyl des-Chlorohalopemide
- FIPI HYDROCHLORIDE
- FIPI