MENSACARCIN

生物活性靶点体外研究

MENSACARCIN

CAS号:: 808750-39-2

英文名:: Mensacarcin

英文别名:: Mensacarcin;(1R,2S,3S,4S,4aS,9aS,10S)-1,2,3,4-Tetrahydro-1,3,4-trihydroxy-5,10-dimethoxy-2-methyl-3-[[(2R,3S)-3-methyloxiranyl]carbonyl]-4a,9a-epoxyanthracen-9(10)-one;4a,9a-Epoxyanthracen-9(10)-one, 1,2,3,4-tetrahydro-1,3,4-trihydroxy-5,10-dimethoxy-2-methyl-3-[[(2R,3S)-3-methyl-2-oxiranyl]carbonyl]-, (1R,2S,3S,4S,4aS,9aS,10S)-

中文名:: MENSACARCIN

中文别名:: 化合物 T12003

CBNumber:: CB82650838

分子式:: C21H24O9

分子量:: 420.40986

MOL File:: 808750-39-2.mol

化学性质安全信息用途供应商 31

MENSACARCIN化学性质

沸点:: 656.8±55.0 °C(Predicted)

密度:: 1.53±0.1 g/cm3(Predicted)

储存条件:: Store at -20°C

溶解度:: DMSO: soluble,Methanol: soluble

形态:: A solid

酸度系数(pKa):: 11.50±0.70(Predicted)

颜色:: White to off-white

安全信息

MENSACARCIN性质、用途与生产工艺

生物活性

Mensacarcin 是一种高度复杂的聚酮类化合物，在肿瘤细胞系中普遍具有强烈的抑制细胞生长的作用，并可能诱导黑色素瘤细胞的凋亡 (apoptosis)。Mensacarcin 靶向线粒体 (mitochondria)，影响线粒体的能量代谢，激活 caspase 依赖的凋亡途径。Mensacarcin 是一种抗生素，也可作为抗体偶联药物 (ADCs) 的细胞毒性成分。

Mensacarcin (0-100 μM; 24 hours) exhibits general cytostatic but type-specific cytotoxic effects for melanoma cells.
Mensacarcin (2-50 μM; 15 hours) induces rapid apoptotic cell death in melanoma cells.
Mensacarcin exhibits potent cytostatic properties (mean of 50% growth inhibition=0.2 μM) in almost all cell lines of the National Cancer Institute (NCI)-60 cell line screen and relatively selective cytotoxicity against melanoma cells. Mensacarcin is a highly oxygenated polyketide that was first isolated from soil-dwelling Streptomyces bacteria. Mensacarcin impairs mitochondrial function in melanoma cells.

Cell Viability Assay

Cell Line:	SK-Mel-28 and SK-Mel-5 melanoma cells, HCT-116 colon cancer cells
Concentration:	0.01, 0.1, 1, 10, 100 μM
Incubation Time:	24 hours
Result:	Induced concentration- and time-dependent cell death in the two tested melanoma cell lines. HCT-116 colon carcinoma cells were strongly inhibited.

Western Blot Analysis

Cell Line:	SK-Mel-28, SK-Mel-5 cells
Concentration:	2, 10, 50 μM
Incubation Time:	15 hours
Result:	Induced the formation of 89-kDa PARP-1 fragments as well as caspase-3 activation in SK-Mel-28 and SK-Mel-5 beginning between 6 and 15 h after exposure.

MENSACARCIN 上下游产品信息

上游原料

下游产品

MENSACARCIN 生产厂家

全球有 31家供应商 MENSACARCIN国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
上海同田生物技术有限公司	021-51320588	tauto@tautobiotech.com	中国	3989	66
上海一飞生物科技有限公司	021-65675885 18964387627	info@efebio.com	中国	9709	58
北京普西唐生物科技有限公司	010-60605840 18892239720	psaitong@jm-bio.com	中国	12308	58
西安莱茵生物科技有限公司	86-(0)29-85992781 17792393971	info@lynnchem.com	中国	4587	58
Novachemistry	44-20819178-90 02081917890	info@novachemistry.com	英国	4381	58
BOC Sciences	+16314854226	inquiry@bocsci.com	美国	19743	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
Hangzhou Huarong Pharm Co., Ltd.	571-86758373 +8613588754946	sales@huarongpharm.com	中国	3149	58
ChemeGen 中国	18818260767	sales@chemegen.com	中国	11289	58
天津普西唐生物医药科技有限公司	010-60605840	psaitong@jm-bio.com	中国	29778	58
上海一研生物科技有限公司	021-69985186 13611928337	3427709316@qq.com	中国	7984	58
南京世洲生物科技有限公司	025-85560043 15850508050	cindy.huang@synzest.com	中国	12007	58
TargetMol中国（陶术生物）	15002134094	marketing@targetmol.com	中国	24246	58
Aladdin Scientific Corporation	+1-833-552-7181	sales@aladdinsci.com	美国	52927	58

808750-39-2, MENSACARCIN 相关搜索:

抑制剂
化合物 T12003
808750-39-2
4a,9a-Epoxyanthracen-9(10)-one, 1,2,3,4-tetrahydro-1,3,4-trihydroxy-5,10-dimethoxy-2-methyl-3-[[(2R,3S)-3-methyl-2-oxiranyl]carbonyl]-, (1R,2S,3S,4S,4aS,9aS,10S)-
(1R,2S,3S,4S,4aS,9aS,10S)-1,2,3,4-Tetrahydro-1,3,4-trihydroxy-5,10-dimethoxy-2-methyl-3-[[(2R,3S)-3-methyloxiranyl]carbonyl]-4a,9a-epoxyanthracen-9(10)-one
Mensacarcin