5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐
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- CAS号:
- 681006-28-0
- 英文名:
- AICAR (phosphate)
- 英文别名:
- AICAR (phosphate);Acadesine phosphate;AICAR phosphate, >98%;AICA Riboside phosphate);AICAR (Acadesine) phosphate;AICA-riboside monophosphate;AICAR phosphate
(Acadesine phosphate;ACADESINE PHOSPHATE;AICA RIBOSIDE PHOSPHATE;5-Amino-1-ribosylimidazole-4-carboxamide phosphate
- 中文名:
- 5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐
- 中文别名:
- 阿卡地新磷酸盐;化合物 T14149;阿卡地新磷酸盐?, >98%;5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐
- CBNumber:
- CB82677075
- 分子式:
- C9H17N4O9P
- 分子量:
- 356.23
- MOL File:
- 681006-28-0.mol
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5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐性质、用途与生产工艺
AICAR phosphate (Acadesine phosphate) 是一种腺苷类似物，也是一种 AMPK 激活剂。AICAR phosphate 调节葡萄糖和脂质的代谢，并抑制促炎细胞因子和 iNOS 的产生。AICAR phosphate 也是一种自噬 (autophagy)，YAP 和 mitophagy 抑制剂。
HepG2 cells are treated with various concentrations of AICAR (0.1-1.0 mM) for 12, 24, and 48 h, respectively. The expression level of IR-β significantly decreases with 0.25, 0.5, and 1.0 mM of AICAR at 48 h to 50%, 53%, and 46% of the control, respectively.
Fourteen-week-old male, lean (L; 31.3 g body wt) wild-type andob/ob (O; 59.6 g body wt) mice are injected with the AMP-activated kinase (AMPK) activator AICAR (A) at 0.5 mg*g body wt
-1
*day
-1
or saline control (C) for 14 days. At 24 h after the last injection (including a 12-h fast), all mice are killed, and the plantar flexor complex muscle (gastrocnemius, soleus, and plantaris) is excised for analysis. Muscle mass is lower in OC (159±12 mg) than LC, LA, and OA (176±10, 178±9, and 166±16 mg, respectively) mice, independent of a body weight change. The kidney weight is significantly higher in the untreated group when compared with both the exercise and AICAR (0.5 mg/g body wt) groups. The heart weight is higher in the exercise group than in the other groups, whereas the liver weight is significantly higher in the AICAR-treated group when compared with the exercise and untreated groups.
5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-13417A | 5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐
AICAR phosphate | 681006-28-0 | 50mg | 520元 |
| 2024/04/30 | HY-13417A | 5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐
AICAR phosphate | 681006-28-0 | 10mM * 1mLin Water | 572元 |
5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐
生产厂家
681006-28-0, 5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐 相关搜索:
- 对照品
- C9H17N4O9P
- C9H14N4O5xH3PO4
- 化合物 T14149
- 阿卡地新磷酸盐
- 阿卡地新磷酸盐?, >98%
- 5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐
- 681006-28-0
- AICA-riboside monophosphate
- ACADESINE PHOSPHATE;AICA RIBOSIDE PHOSPHATE
- Acadesine phosphate
- AICAR phosphate
(Acadesine phosphate
- AICA Riboside phosphate)
- AICAR phosphate, >98%
- AICAR (Acadesine) phosphate
- 5-Amino-1-ribosylimidazole-4-carboxamide phosphate
- AICAR (phosphate)