6RK73
|
|
|
- CAS号:
- 1895050-66-4
- 英文名:
- 6RK73
- 英文别名:
- 6RK73;6RK-73,6RK73;3-Pyrrolidinecarboxamide, 1-cyano-N-[5-(4-morpholinyl)-2-thiazolyl]-, (3S)-
- 中文名:
- 6RK73
- 中文别名:
- 化合物6RK73;化合物 T10188
- CBNumber:
- CB88054296
- 分子式:
- C13H17N5O2S
- 分子量:
- 307.37
- MOL File:
- 1895050-66-4.mol
|
|
|
6RK73化学性质
-
密度:
-
1.41±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
酸度系数(pKa):
-
8.04±0.70(Predicted)
-
|
6RK73性质、用途与生产工艺
6RK73 是一种共价不可逆的特异性 UCHL1 抑制剂，IC50 为 0.23 µM。6RK73 对 UCHL3 几乎没有抑制效果 (IC50=236 µM)。6RK73 特异性抑制乳腺癌中 UCHL1 的活性。
IC50: 0.23 µM (UCHL1), 236 µM (UCHL3)
6RK73 (5 µM; 1-3 hours) treatment displays strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels in MDA-MB-436 cells.
6RK73(5 µM; 24-48 hours) results migration significantly slower than the DMSO control group in MDA-MB-436 cells.
Cell Viability Assay
|
Cell Line:
|
MDA-MB-436 cells
|
|
Concentration:
|
5 µM
|
|
Incubation Time:
|
24, 48 hours
|
|
Result:
|
Migrated significantly slower than the DMSO control group
|
Western Blot Analysis
|
Cell Line:
|
MDA-MB-436 cells
|
|
Concentration:
|
5 µM
|
|
Incubation Time:
|
1, 2, 3 hours
|
|
Result:
|
Displayed strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels.
|
6RK73 displays a potent inhibition of breast cancer extravasation in zebrafish.
6RK73
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-133118 | 6RK73 | | 1 mg | 1447元 |
| 2024/04/30 | HY-133118 | 6RK73
6RK73 | 1895050-66-4 | 10mM * 1mLin DMSO | 4180元 |
1895050-66-4, 6RK73 相关搜索:
- 制剂-抑制剂
- 化合物6RK73
- 化合物 T10188
- 1895050-66-4
- 3-Pyrrolidinecarboxamide, 1-cyano-N-[5-(4-morpholinyl)-2-thiazolyl]-, (3S)-
- 6RK-73,6RK73
- 6RK73