2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸
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- CAS号:
- 68003-38-3
- 英文名:
- 2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid
- 英文别名:
- ABD7;ABD-7;ABD 7;Einecs 268-121-3;SLC25A1 inhibitor CTPI-2;2-(4-Chloro-3-nitrophenylsulfonamido)benzoic Acid;2-(4'-Chloro-3'-nitrobenzenesulfonamido)benzoic acid;2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid;Benzoic acid, 2-(((4-chloro-3-nitrophenyl)sulfonyl)amino)-;2-(4-Chloro-3-nitrophenylsulfonylamino)benzenecarboxylic acid
- 中文名:
- 2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸
- 中文别名:
- 化合物CTPI-2;2-(4-氯-3-硝基苯基磺酰氨基)苯甲酸;2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸
- CBNumber:
- CB8884338
- 分子式:
- C13H9ClN2O6S
- 分子量:
- 356.74
- MOL File:
- 68003-38-3.mol
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2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸化学性质
2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸性质、用途与生产工艺
CTPI-2 是一种线粒体柠檬酸盐载体 SLC25A1 的抑制剂，KD值为3.5 μM。CTPI-2 是 glycolysis 的独特调节剂，它限制了癌症干细胞(CSCs)的代谢可塑性。
| Target | Value |
glycolysis
()
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SLC25A1
(Cell-free assay)
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3.5 μM(Kd)
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CTPI-2 is a unique regulator of glycolysis that limits the metabolic plasticity of cancer stem cells (CSCs). CTPI-2 (26 mg/kg; i.p.) inhibits tumor growth in in vivo models of non-small cell lung cancer (NSCLC).
CTPI-2 (50 mg/kg; i.p.; alternate days for 12 weeks) completely averts weight gain in the prevention study and leads to significant weight loss in the reversion study.
CTPI-2 prevents steatohepatitis and normalizes glucose tolerance. CTPI-2 lowers the levels of circulating IL-6 while increasing anti-inflammatory IL-4 and IL-10 and also reduced the monocyte chemoattractant protein-1 and monokine-induced by interferon-γ that attract neutrophils and monocytes. CTPI-2 regulates the citrate pool, the lipogenic and the gluconeogenic pathways.
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Animal Model:
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C57BL/6J mice (HFD-fed mice)
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Dosage:
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50 mg/kg
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Administration:
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Alternate days via the intraperitoneal route for 12 weeks
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Result:
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Completely averted weight gain in the prevention study and led to significant weight loss in the reversion study.
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2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | S2968 | 2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸
CTPI-2 | 68003-38-3 | 5mg | 1384.11元 |
| 2024/04/30 | S2968 | CTPI-2 | 68003-38-3 | 10mM (1mL in DMSO) | 1613.43元 |
2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸
生产厂家
68003-38-3, 2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸 相关搜索:
- 药靶配体
- 2-(4-氯-3-硝基苯基磺酰氨基)苯甲酸
- 化合物CTPI-2
- 2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸
- 68003-38-3
- ABD-7
- ABD7
- ABD 7
- 2-(4-Chloro-3-nitrophenylsulfonamido)benzoic Acid
- macrophage,carrier,CTPI-2,NSCLC,transporter,glucose,steatohepatitis,CTPI 2,Mitochondrial Metabolism,steatosis,inflammatory,inhibit,citrate,Inhibitor,mitochondrial,CTPI2
- SLC25A1 inhibitor CTPI-2
- 2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid
- Einecs 268-121-3
- Benzoic acid, 2-(((4-chloro-3-nitrophenyl)sulfonyl)amino)-
- 2-(4'-Chloro-3'-nitrobenzenesulfonamido)benzoic acid
- 2-(4-Chloro-3-nitrophenylsulfonylamino)benzenecarboxylic acid