186971-69-7
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- CAS号:
- 186971-69-7
- 英文名:
- TAK 024
- 英文别名:
- TAK 024;TAK 024,TAK024;1-Piperazineacetic acid, 4-[2-[[4-[(aminoiminomethyl)amino]benzoyl]amino]acetyl]-3-[3-[[4-[(aminoiminomethyl)amino]benzoyl]amino]propyl]-2-oxo-, (3S)-
- 中文名:
- 186971-69-7
- 中文别名:
- 化合物 T13065
- CBNumber:
- CB91346892
- 分子式:
- C27H34N10O6
- 分子量:
- 594.62
- MOL File:
- 186971-69-7.mol
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186971-69-7化学性质
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熔点:
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245-251.5 °C
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密度:
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1.51±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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3.66±0.10(Predicted)
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186971-69-7性质、用途与生产工艺
TAK-024 是一种血小板抑制剂,在人,猴和豚鼠中的 IC50 值分别为 31, 79 和 51 nM。
IC50: 31 nM (human platelet), 79 nM (monkey platelet), 51 nM (pig platelet)
TAK-024 is a platelet inhibitor with IC
50
s of 31, 79 and 51 nM in human, monkey and guinea pig, respectively. In a preliminary experiment, the IC
50
value of TAK-024 in the heparinized blood sample is 230 nM, 4.5-fold less potent than that in the citrated physiological blood sample. The ID
50
value of TAK-024 on
ex vivo
ADP-induced platelet aggregation in guinea pigs is 0.18 μg/kg/min, the dissociation ratio of TAK-024 is found to be 32.
Intravenous infusion of TAK-024 (compound 12c) at 1.6 μg/mL/min completely prevents arterial thrombus formation induced by endothelial injury in guinea pigs. Results demonstrate the inhibitory effects of TAK-024 on the carotid thrombosis induced by balloon injury in guinea pigs and the ID
50
value is 0.73 μg/kg/min. A single dose of TAK-024 at 100 μg/kg iv produces almost complete inhibition for 120 min, and about 40% inhibition is observed after 240 min. Dose-dependent inhibition of platelet aggregation is achieved with a single iv dose of 30 to 100 μg/kg of TAK-024.
186971-69-7
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186971-69-7, 186971-69-7 相关搜索:
- C27H34N10O6
- 化合物 T13065
- 186971-69-7
- TAK 024,TAK024
- 1-Piperazineacetic acid, 4-[2-[[4-[(aminoiminomethyl)amino]benzoyl]amino]acetyl]-3-[3-[[4-[(aminoiminomethyl)amino]benzoyl]amino]propyl]-2-oxo-, (3S)-
- TAK 024