PVM/MA共聚物
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- CAS号:
- 1644545-52-7
- 英文名:
- PVM/MA
- 英文别名:
- AG881;E7386;AG081;HS-01;PVM/MA;AG-881;E-7386;s-22611;FF10101;CS-2621
- 中文名:
- PVM/MA共聚物
- 中文别名:
- 氨基羧基磁珠;多功能钢铁表面处理浓缩液;生产厂家3.5-二甲基苯酚;生产厂家2.2-二氟乙醇成品;IDH抑制剂(VORASIDENIB);VORASIDENIB (AG-881),抑制剂;(S)-1-氨基-1-(5-溴-2-氟苯基)乙烷-1-醇;4-IODOBUTYRIC ACID NHS ESTER;3-IODOPROPANESULFONYL FLUORIDE;4-(2-乙酰基-5-氯苯基)-5-甲氧基吡啶-2(1H)-酮
- CBNumber:
- CB91403717
- 分子式:
- C14H13ClF6N6
- 分子量:
- 414.74
- MOL File:
- 1644545-52-7.mol
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PVM/MA共聚物化学性质
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沸点:
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467.5±55.0 °C(Predicted)
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密度:
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1.491±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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1.49±0.41(Predicted)
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PVM/MA共聚物性质、用途与生产工艺
Vorasidenib (AG-881)是一种具有口服活性的抑制剂，靶向突变型IDH1和IDH2。
| Target | Value |
IDH1
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IDH2
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泛IDH1/2抑制剂（AG881）选择性地抑制突变型IDH蛋白，并在体内外模型中诱导细胞分化。 AG-881抑制α-KG转变成癌代谢物2HG，抑制2HG介导的信号、并引起细胞分化、表达突变型IDH的肿瘤细胞增殖受到抑制。
AG-881可完全穿过血脑屏障。目前AG-881处于临床早期I期试验，检测其对治疗具有IDH突变的恶性血液病、实体肿瘤、胶质瘤的效果。
PVM/MA共聚物
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | XW164454552701 | 试剂Vorasidenib (AG-881)
Vorasidenib (AG-881) | | 5mg | 199元 |
| 2024/04/30 | XW164454552702 | 试剂Vorasidenib (AG-881)
Vorasidenib (AG-881) | | 25mg | 578元 |
1644545-52-7, PVM/MA共聚物 相关搜索:
- api
- Dimethoxyamphetamine
- 合成有机化合物配体
- 黄金产品
- 有机化工
- 化工中间体
- 粉末类
- 抑制剂
- 细胞生物学试剂
- 嘧啶系列
- C14H13ClF6N6
- 00-00-0
- VORASIDENIB (AG-881),抑制剂
- 4-IODOBUTYRIC ACID NHS ESTER
- 4-PYRIDONE-N-TETRAFLUOROPROPIONIC ACID CS SALT
- PYRAZOLYLTETRAFLUOROPROPIONIC ACID CS SALT
- 2-PYRIDONE-N-TETRAFLUOROPROPIONIC ACID CS SALT
- 3,5-DIMETHYLPYRAZOLYLTETRAFLUOROPROPIONIC ACID CS SALT
- 2,4-DICHLOROPHENOXYTETRAFLUOROPROPIONIC ACID CS SALT
- 4-CHLORPHENOXYTETRAFLUOROPROPIONIC ACID CS SALT
- 4-METHOXYPHENOXYTETRAFLUOROPROPIONIC ACID CS SALT
- PHENOXYTETRAFLUOROPROPIONIC ACID CS SALT
- 3-TRIFLUOROMETHYLPHENOXYTETRAFLUOROPROPIONIC CS SALT
- 4-FLUOROPHENOXYTETRAFLUOROPROPIONIC ACID CS SALT
- 3-IODOPROPANESULFONYL FLUORIDE
- ALCOHOL TOGNI-(4-F-PHOCF2CF2)-REAGENT
- 4-CYANOPHENOXYTETRAFLUOROETHYL TRIMETHYLSILANE
- ACID TOGNI-(4-F-PHOCF2CF2)-REAGENT
- ALCOHOL TOGNI-(4-CL-PHOCF2CF2)-REAGENT
- ALCOHOL TOGNI-(3,5-DIME-PYRAZOLYLCF2CF2)-REAGENT
- ACID TOGNI-(3-CF3-PHOCF2CF2)-REAGENT
- 1-DIFLUOROMETHYLTRIAZOLYL-4-CARBOXAMIDE
- 1-(TRIFLUOROMETHYL)-1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE
- (1-(2,2-DIFLUOROETHYL)-1H-1,2,3-TRIAZOL-4-YL)METHANAMINE HYDROCHLORIDE
- (S)-1-氨基-1-(5-溴-2-氟苯基)乙烷-1-醇
- 2-(1-乙氧基乙烯基)-4,4,5,5-四乙基-1,3,2-二氧杂硼烷
- 生产厂家3.5-二甲基苯酚
- 生产厂家2.2-二氟乙醇成品
- 6-(6-氯吡啶-2-基)-N2,N4-双((R)-1,1,1-三氟丙烷-2-基)-1,3,5-三嗪-2,4-二胺
- 多功能钢铁表面处理浓缩液
- IDH抑制剂(VORASIDENIB)
- 氨基羧基磁珠
- 4-(2-乙酰基-5-氯苯基)-5-甲氧基吡啶-2(1H)-酮
- 1644545-52-7
- spiro[fluorene-9,9'-xanthen]-2'-ylboronic acid
- (2-(4-Cyanophenoxy)-1,1,2,2-tetrafluoroethyl)trimethylsilane
- 3,3-Dimethyl-1-(1,1,2,2-tetrafluoro-2-(4-fluorophenoxy)ethyl)-1,3-dihydro-1λ3-benzo[d][1,2]iodaoxole
- 3-Iodopropane-1-sulfonyl fluoride
- 2-(1H-Benzo[d]imidazol-1-yl)-1,1,2,2-tetrafluoroethane-1-sulfonyl fluoride
- Cesium 3-(4-methoxyphenoxy)-2,2,3,3-tetrafluoropropanoate
- Cesium 3-(2,4-dichlorophenoxy)-2,2,3,3-tetrafluoropropanoate
- Cesium 2,2,3,3-tetrafluoro-3-(phenylthio)propanoate
- Cesium 3-(4-bromophenoxy)-2,2,3,3-tetrafluoropropanoate
- Cesium 3-(4-(ethoxycarbonyl)phenoxy)-2,2,3,3-tetrafluoropropanoate
- Cesium 3-(phenoxy)-2,2,3,3-tetrafluoropropanoate
- Cesium 3-(3-(trifluoromethyl)phenoxy)-2,2,3,3-tetrafluoropropanoate
- Cesium 2,2,3,3-tetrafluoro-3-(1H-imidazol-1-yl)propanoate
- Cesium 2,2,3,3-tetrafluoro-3-(2-oxopyridin-1(2H)-yl)propanoate