SIRT1/2 INHIBITOR IV
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- CAS号:
- 14513-15-6
- 英文名:
- NSC-1125476, Tetrahydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-Pyrimidinone, 5-(2-Hydroxynaphthalen-1-ylmethyl)-6-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one, 5-[(2-hydroxy-1-naphthyl)methyl]-2-mercapto-6-phenyl-4(3H)-Pyrimidinone
- 英文别名:
- Cambinol;NSC 112546;NSC-1125476;CAMBINOL;NSC-1125476;SIRT1/2 Inhibitor IV;Cambinol - NSC 112546;SIRT1/2 Inhibitor IV, Cambinol;5-[(2-hydroxy-1-naphthyl)methyl]-2-mercapto-6-phenyl-4(3H)-Pyrimidinone;5-[(2-Hydroxy-1-naphthyl)methyl]-6-phenyl-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone;5-(2-Hydroxynaphthalen-1-ylmethyl)-6-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one
- 中文名:
- SIRT1/2 INHIBITOR IV
- 中文别名:
- 化合物CAMBINOL;CAMBINOL,SIRT1 / 2抑制剂;SIRT1和SIRT1抑制剂(CAMBINOL);5-[(2-羟基萘-1-基)甲基]-6-苯基-2-硫代-2,3-二氢嘧啶-4(1H)-酮;5-((2-羟基萘-1-基)甲基)-6-苯基-2-硫氧代-2,3-二氢嘧啶-4(1H)-酮
- CBNumber:
- CB92099412
- 分子式:
- C21H16N2O2S
- 分子量:
- 360.43
- MOL File:
- 14513-15-6.mol
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SIRT1/2 INHIBITOR IV化学性质
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熔点:
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235 °C(dec.)
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密度:
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1.41±0.1 g/cm3(Predicted)
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储存条件:
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room temp
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溶解度:
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DMSO: ≥10mg/mL
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形态:
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White solid
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酸度系数(pKa):
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7.24±0.25(Predicted)
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颜色:
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White to Off-White
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SIRT1/2 INHIBITOR IV性质、用途与生产工艺
Cambinol是一种新型的、非竞争性的nSMase2抑制剂,Ki值为7 μM。
Target | Value |
nSMase2
(Cell-free assay)
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7 μM(Ki)
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Cambinol inhibits NAD-dependent deacetylase activity of human SIRT1 and SIRT2. Inhibition of SIRT1 activity with cambinol during genotoxic stress leads to hyperacetylation of key stress response proteins and promotes cell cycle arrest. Treatment of BCL6-expressing Burkitt lymphoma cells with cambinol as a single agent induces apoptosis, which is accompanied by hyperacetylation of BCL6 and p53. Cambinol has only weak inhibitory activity against SIRT5 (42% inhibition at 300 μM) and no activity against SIRT3.
Cambinol is well tolerated in mice (100 mg/kg) and inhibits growth of Burkitt lymphoma xenografts. No significant weight loss occurs in cambinol-treated animals relative to controls. Inhibitors of NAD-dependent deacetylases may constitute novel anticancer agents.
SIRT1/2 INHIBITOR IV
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | C3535 | Cambinol Cambinol | 14513-15-6 | 5mg | 250元 |
2024/04/30 | C3535 | Cambinol Cambinol | 14513-15-6 | 25mg | 990元 |
SIRT1/2 INHIBITOR IV
生产厂家
14513-15-6, SIRT1/2 INHIBITOR IV 相关搜索:
- 生化试剂
- 细胞生物学试剂
- 5-((2-羟基萘-1-基)甲基)-6-苯基-2-硫氧代-2,3-二氢嘧啶-4(1H)-酮
- CAMBINOL,SIRT1 / 2抑制剂
- 化合物CAMBINOL
- SIRT1和SIRT1抑制剂(CAMBINOL)
- 5-[(2-羟基萘-1-基)甲基]-6-苯基-2-硫代-2,3-二氢嘧啶-4(1H)-酮
- 14513-15-6
- 5-[(2-Hydroxynaphthalen-1-yl)methyl]-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
- 5-[(2-Hydroxy-1-naphthyl)methyl]-6-phenyl-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone
- 4(1H)-Pyrimidinone, 2,3-dihydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-
- NSC-1125476, Tetrahydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-Pyrimidinone, 5-(2-Hydroxynaphthalen-1-ylmethyl)-6-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one, 5-[(2-hydroxy-1-naphthyl)methyl]-2-mercapto-6-phenyl-4(3H)-Pyrimidin
- NSC 112546
- Cambinol - NSC 112546
- CAMBINOL;NSC-1125476
- 5-[(2-hydroxy-1-naphthyl)methyl]-2-mercapto-6-phenyl-4(3H)-Pyrimidinone
- 5-(2-Hydroxynaphthalen-1-ylmethyl)-6-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one
- NSC-1125476, Tetrahydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-Pyrimidinone, 5-(2-Hydroxynaphthalen-1-ylmethyl)-6-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one, 5-[(2-hydroxy-1-naphthyl)methyl]-2-mercapto-6-phenyl-4(3H)-Pyrimidinone
- Cambinol
- SIRT1/2 Inhibitor IV
- SIRT1/2 Inhibitor IV, Cambinol
- Tetrahydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-Pyrimidinone
- NSC-1125476