SULINDAC
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- CAS号:
- 49627-27-2
- 英文名:
- SULINDAC SULFIDE
- 英文别名:
- Einecs 256-403-9;SULINDAC SULPHIDE;(Z)-Sulindac sulfide;cis-Sulindac sulfide;Sulindac Impurity N92;Sulindac USP Related Compound C;Sulindac EP Impurity C (Sulindac Sulfide);Sulindac Impurity 3（Sulindac EP Impurity C）;(Z)-5-FLUORO-2-METHYL-1-[P-(METHYLTHIO)BENZYLIDENE]INDENE-3-ACETIC ACID;(Z)-5-FLUORO-2-METHYL-1-(4-METHYLTHIOBENZYLIDENE)-1H-INDEN-3-YLACETIC ACID
- 中文名:
- SULINDAC
- 中文别名:
- 舒林酸硫醚;舒林酸杂质N92;舒林酸EP杂质C;化合物 T13037;舒林酸相关化合物C(USP);舒林酸EP杂质C(舒林酸硫化物);(Z)-5-氟-2-甲基-1-[4-(甲硫苯基)亚甲基]-1H-茚-3-醋酸
- CBNumber:
- CB9211728
- 分子式:
- C20H17FO2S
- 分子量:
- 340.41
- MOL File:
- 49627-27-2.mol
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SULINDAC化学性质
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熔点:
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189-191°C
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储存条件:
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-20°C Freezer
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溶解度:
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DMSO: >22 mg/mL
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形态:
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solid
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颜色:
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yellow
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SULINDAC性质、用途与生产工艺
Sulindac sulfide 是 γ-secretase 的一个非竞争性抑制剂，其对 γ42-secretase 的 IC50 值为 20.2 μM。
IC50: 20.2 μM (γ
42
-secretase).
Treatment with 100 μM of Sulindac sulfide (SSide) causes cell death presumably by inducing apoptosis, resulting in marked decrease in Aβgeneration as well as in total protein expression. The IC
50
value for Aβ42 secretion of Sulindac sulfide is 30.6±2.8 μM. SSone and naproxen have no effect either on Aβ40 or Aβ42 secretion as well as on Notch cleavage up to 100 μM. It is observed that an inhibition of γ
42
-secretase activity by Sulindac sulfide in a dose-dependent manner. The IC
50
value of SSide for inhibiting γ
42
-secretase activity in vitro is 20.2±2.6 μM. A decrease is found in slope by the increase of the concentration of SSide in the plot of rate against the enzyme concentration, suggesting that Sulindac sulfide is not an irreversible or pseudo-irreversible inhibitor. Moreover, when the dialyzed solubilizedγ-secretase fraction is pretreated with Sulindac sulfide against CHAPSO buffer without Sulindac sulfide, γ-secretase activity is almost totally recovered. From these data, it is strongly suggested that the genuine molecular target of Sulindac sulfide is the γ-secretase complex and that Sulindac sulfide works as a reversible γ-secretase inhibitor.
SULINDAC
上下游产品信息
上游原料
下游产品
49627-27-2, SULINDAC 相关搜索:
- Pharmaceuticals
- Metabolites
- Intermediates & Fine Chemicals
- G Proteins and Cyclic Nucleotides
- G Protein Function
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- Reagents
- 舒林酸杂质N92
- 舒林酸EP杂质C(舒林酸硫化物)
- (Z)-5-氟-2-甲基-1-[4-(甲硫苯基)亚甲基]-1H-茚-3-醋酸
- 舒林酸硫醚
- 舒林酸相关化合物C(USP)
- 舒林酸EP杂质C
- 化合物 T13037
- 49627-27-2
- Sulindac Impurity N92
- Sulindac EP Impurity C (Sulindac USP Related Compound C, Sulindac Sulfide)
- (Z)-2-{5-fluoro-2-methyl-1-[4-(methylthio)benzylidene]-1H-inden-3-yl}acetic acid
- Sulindac USP Related Compound C
- Sulindac Related Compound C ((Z)-2-{5-fluoro-2-methyl-1-[4-(methylthio)benzylidene]-1H-inden-3-yl}a (1642031)
- 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (1Z)-
- Sulindac EP Impurity C (Sulindac Sulfide)
- cis-Sulindac sulfide
- Sulindac Impurity 3（Sulindac EP Impurity C）
- (Z)-5-FLUORO-2-METHYL-1-[P-(METHYLTHIO)BENZYLIDENE]INDENE-3-ACETIC ACID
- SULINDAC SULPHIDE
- Einecs 256-403-9
- 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylthio)phenyl)methylene)-, (Z)-
- (Z)-Sulindac sulfide
- 5-Fluoro-2-methyl-1-[(Z)-[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid
- (Z)-5-FLUORO-2-METHYL-1-(4-METHYLTHIOBENZYLIDENE)-1H-INDEN-3-YLACETIC ACID
- (Z)-5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid