CARBOXYAMIDOTRIAZOLE OROTATE
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- CAS号:
- 187739-60-2
- 英文名:
- CARBOXYAMIDOTRIAZOLE OROTATE
- 英文别名:
- CAI Orotate;L-651582 Orotate;OCSMDRBVJRAMCI-UHFFFAOYSA-N;CARBOXYAMIDOTRIAZOLE OROTATE;L651582,Inhibitor,toxicity,Calcium Channel,L 651582,Ca2+ channels,Ca channels,leukaemia,inhibit,ovarian,chronic,Carboxyamidotriazole,Carboxyamidotriazole Orotate,CAI,Bcr/Abl,L-651582,cancer,myelogenous
- 中文名:
- CARBOXYAMIDOTRIAZOLE OROTATE
- 中文别名:
- 化合物CARBOXYAMIDOTRIAZOLE OROTATE
- CBNumber:
- CB92627668
- 分子式:
- C22H16Cl3N7O6
- 分子量:
- 580.76
- MOL File:
- 187739-60-2.mol
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CARBOXYAMIDOTRIAZOLE OROTATE化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 5 mg/mL (8.61 mM)
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CARBOXYAMIDOTRIAZOLE OROTATE性质、用途与生产工艺
Carboxyamidotriazole Orotate (L-651582 Orotate)，是一种口服生物有效的信号转导抑制剂Carboxyamidotriazole (CAI) 的 orotate 盐形式。Carboxyamidotriazole Orotate 是一种非电压性钙通道 (nonvoltage-operated calcium channels) 和钙通道介导的信号通路 (calcium channel-mediated signaling pathways) 的细胞抑制剂，具有抗癌，抗炎活性和抗血管生成作用。
Carboxyamidotriazole Orotate (0.1-10 µM; 24-96 hours) inhibits cell proliferation of LAMA84R and K562R cell lines.
Carboxyamidotriazole Orotate inhibits the phosphorylation of a selected target of Bcr-Abl kinase. Tyrosine phosphorylation of CrkL is reduced by 5 µM Carboxyamidotriazole Orotate treatment.
Cell Viability Assay
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Cell Line:
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LAMA84R and K562R cell lines
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Concentration:
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0.1, 1, 5, 10 µM
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Incubation Time:
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24, 48, 72, 96 hours
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Result:
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Showed a 50% growth reduction of the chronic myelogenous leukaemia (CML) lines with 5 µM CTO at 96 h time point.
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Western Blot Analysis
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Cell Line:
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LAMA84R and K562R cell lines
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Concentration:
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0.1, 1, 5 µM
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Incubation Time:
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72 and 96 hours
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Result:
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A dose-dependent inhibition of both total and phosphorylated Bcr-Abl levels.
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Carboxyamidotriazole Orotate (342, 513 mg/kg; i.p.; Q1D×5 for two rounds) displays antitumor activity on CML xenografts.
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Animal Model:
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Male NOD/SCID mice four-to-five week old
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Dosage:
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342, 513 mg/kg
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Administration:
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i.p.; Q1D×5 for two rounds
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Result:
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Increase survival.
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CARBOXYAMIDOTRIAZOLE OROTATE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-16125 | CARBOXYAMIDOTRIAZOLE OROTATE
Carboxyamidotriazole Orotate | 187739-60-2 | 5mg | 2000元 |
| 2024/04/30 | S2975 | CarboxyaMidotriazole orotate | 187739-60-2 | 5mg | 2211.3元 |
CARBOXYAMIDOTRIAZOLE OROTATE
生产厂家
187739-60-2, CARBOXYAMIDOTRIAZOLE OROTATE 相关搜索:
- 化合物CARBOXYAMIDOTRIAZOLE OROTATE
- 187739-60-2
- L651582,Inhibitor,toxicity,Calcium Channel,L 651582,Ca2+ channels,Ca channels,leukaemia,inhibit,ovarian,chronic,Carboxyamidotriazole,Carboxyamidotriazole Orotate,CAI,Bcr/Abl,L-651582,cancer,myelogenous
- L-651582 Orotate
- CAI Orotate
- OCSMDRBVJRAMCI-UHFFFAOYSA-N
- CARBOXYAMIDOTRIAZOLE OROTATE