TD-198946
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- CAS号:
- 364762-86-7
- 英文名:
- TD-198946
- 英文别名:
- TD-198946;TD-198946, >98%;TD198946;TD 198946;TD-198946,inhibit,Inhibitor;1-(3-PYRIDINYLMETHYL)-4-PIPERIDINOL DIHYDROCHLORIDE;1H-THIENO[3,4-G]INDAZOLE-6-CARBOXAMIDE, 4,5-DIHYDRO-1-METHYL-8-[4-(2-QUIN+;4,5-dihydro-1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-1H-thieno[3,4-g]indazole-6-carboxamide;1-Methyl-8-(4-(quinolin-2-ylmethoxy)phenoxy)-4,5-dihydro-1H-thieno[3,4-g]indazole-6-carboxamide;1-Methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-4,5-dihydro-1H-thieno [3,4-g]indazole-6-carboxamide;1H-Thieno[3,4-g]indazole-6-carboxamide, 4,5-dihydro-1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-
- 中文名:
- TD-198946
- 中文别名:
- 化合物TD198946;1-甲基-8-(4-(喹啉-2-甲氧基)苯氧基)-4,5-二氢-1H-噻吩并[3,4-G]吲唑-6-甲酰胺;TD-198946 (1-METHYL-8-[4-(2-QUINOLINYLMETHOXY)PHENOXY]-4,5-DIHYDRO-1H-THIENO [3,4-G]INDAZOLE-6-CARBOXAMIDE)
- CBNumber:
- CB92655421
- 分子式:
- C27H22N4O3S
- 分子量:
- 482.55
- MOL File:
- 364762-86-7.mol
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TD-198946化学性质
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沸点:
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699.5±55.0 °C(Predicted)
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密度:
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1.43±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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15.87±0.20(Predicted)
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TD-198946性质、用途与生产工艺
TD-198946是一种噻吩并唑衍生物。它是一种高效的软骨形成剂。
TD-198946 is a potent chondrogenic agent. TD-198946 strongly induces chondrogenic differentiation without promoting hypertrophy in cell and metatarsal organ cultures. TD-198946 induces stronger
Col2a1
promoter activity than insulin in ATDC5 cells. In C3H10T1/2 cells, ATDC5 cells and primary mouse chondrocytes, TD-198946 dose-dependently stimulates endogenous expression of the chondrocyte markers
Col2a1
and
Acan
, with maximum effects around 1-10 μM.
When administered directly into the joint space, TD-198946 successfully prevents and repaires degeneration of the articular cartilage. TD-198946 exerts its effect through the regulation of Runx1 expression, which is downregulated in both mouse and human OA cartilage compared with normal tissue. TD-198946 has disease-modifying effects on progressed osteoarthritis. TD-198946 may prevent the progression of osteoarthritis by acting on the remaining chondrocytes rather than repairing damaged cartilage, it may be most effective as a therapeutic during the early or middle stages of osteoarthritis, before the articular cartilage is fully eroded. Cartilaginous cell-sheets are generated by culturing mouse and canine costal chondrocytes and human mesenchymal stem cells with TD-198946 on temperature-responsive dishes. The transplanted cell-sheets are then successfully used to promote the reconstruction of permanent cartilage, with no evidence of chondrocyte hypertrophy in the knee articular cartilage defects created in mice and canines.
TD-198946
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-15642 | TD-198946
TD-198946 | 364762-86-7 | 1mg | 1142元 |
| 2024/04/30 | HY-15642 | TD-198946
TD-198946 | 364762-86-7 | 5mg | 2200元 |
364762-86-7, TD-198946 相关搜索:
- 1-甲基-8-(4-(喹啉-2-甲氧基)苯氧基)-4,5-二氢-1H-噻吩并[3,4-G]吲唑-6-甲酰胺
- 化合物TD198946
- TD-198946 (1-METHYL-8-[4-(2-QUINOLINYLMETHOXY)PHENOXY]-4,5-DIHYDRO-1H-THIENO [3,4-G]INDAZOLE-6-CARBOXAMIDE)
- 364762-86-7
- 1H-THIENO[3,4-G]INDAZOLE-6-CARBOXAMIDE, 4,5-DIHYDRO-1-METHYL-8-[4-(2-QUIN+
- 1-Methyl-8-(4-(quinolin-2-ylmethoxy)phenoxy)-4,5-dihydro-1H-thieno[3,4-g]indazole-6-carboxamide
- TD-198946,inhibit,Inhibitor
- 1H-Thieno[3,4-g]indazole-6-carboxamide, 4,5-dihydro-1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-
- TD-198946 (1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-4,5-dihydro-1h-thieno [3,4-g]indazole-6-carboxamide)
- TD-198946, >98%
- TD198946;TD 198946
- 4,5-dihydro-1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-1H-thieno[3,4-g]indazole-6-carboxamide
- 1-Methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-4,5-dihydro-1H-thieno [3,4-g]indazole-6-carboxamide
- 1-(3-PYRIDINYLMETHYL)-4-PIPERIDINOL DIHYDROCHLORIDE
- TD-198946