HATU
- CAS No.
- 148893-10-1
- Chemical Name:
- HATU
- Synonyms
- 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate;2-(7-AZA-1H-BENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate(V);O-(7-AZABENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetraMethyluroniuM hexafluorophosphate(V);[bis(dimethylamino)methylidene]({3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl})oxidanium;1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, ChemDoseTM tablets;2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium;1-[BIS(DIMETHYLAMINO)METHYLENE]-1 H-1,2,3-TRIAZOLO(4,5-B) PYRIDINIUM 3-OXIDE HEXAFLUOROPHOSPHATE;N-[(Dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylidene]-N-methylmethylaminium hexafluorophosphate
- CBNumber:
- CB0122630
- Molecular Formula:
- C10H15F6N6OP
- Molecular Weight:
- 380.24
- MDL Number:
- MFCD00274639
- MOL File:
- 148893-10-1.mol
Melting point | 183-188 °C (dec.) |
---|---|
RTECS | XZ5633000 |
storage temp. | 2-8°C |
solubility | >16mg/mL in DMSO |
form | powder to crystaline |
color | White to Almost white |
Water Solubility | Soluble in acetonitrile. Insoluble in water. |
InChI | InChI=1S/C10H15N6O.F6P/c1-13(2)10(14(3)4)15-8-6-5-7-11-9(8)16(17)12-15;1-7(2,3,4,5)6/h5-7H,1-4H3;/q+1;-1 |
InChIKey | KZAWCZZRROLLDL-UHFFFAOYSA-N |
SMILES | [P+5]([F-])([F-])([F-])([F-])([F-])[F-].C(=[N+]1/N=N(=O)C2=NC=CC=C/12)(\N(C)C)/N(C)C |
CAS DataBase Reference | 148893-10-1(CAS DataBase Reference) |
FDA UNII | B93RIH1T7E |
EPA Substance Registry System | 1H-1,2,3-Triazolo[4,5-b]pyridinium, 1-[bis(dimethylamino)methylene]-, hexafluorophosphate(1-), 3-oxide (148893-10-1) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS08 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H317-H334 | |||||||||
Precautionary statements | P261-P272-P280-P284-P302+P352-P304+P340+P312 | |||||||||
Hazard Codes | Xi,Xn,E | |||||||||
Risk Statements | 36/37/38-20/21/22-2 | |||||||||
Safety Statements | 26-37/39-36/37-36-35 | |||||||||
RIDADR | 1325 | |||||||||
WGK Germany | 3 | |||||||||
F | 10-21 | |||||||||
HazardClass | 4.1 | |||||||||
PackingGroup | Ⅱ | |||||||||
HS Code | 29339999 | |||||||||
NFPA 704 |
|
HATU price More Price(66)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 445460 | HATU 97% | 148893-10-1 | 1g | $64.5 | 2024-03-01 | Buy |
Sigma-Aldrich | 8.51013 | HATU Novabiochem? | 148893-10-1 | 25g | $518 | 2024-03-01 | Buy |
Sigma-Aldrich | 8.51013 | HATU Novabiochem? | 148893-10-1 | 100g | $742 | 2024-03-01 | Buy |
Sigma-Aldrich | 445460 | HATU 97% | 148893-10-1 | 5g | $119 | 2024-03-01 | Buy |
TCI Chemical | A1797 | O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Hexafluorophosphate >98.0%(HPLC) | 148893-10-1 | 5g | $111 | 2024-03-01 | Buy |
HATU Chemical Properties,Uses,Production
Description
HATU, first prepared by Louis A. Carpino in 1993, is widely used in carboxylic acid amidation reactions. It acts as a facilitator of amide bond generation by activating the carboxyl group.
Chemical Properties
White crystalline to off-white powder
Uses
HATU[148893-10-1] is a coupling reagent and used as an additive in peptide synthesis. It is also involved efficiently to speed up the coupling process and reduces the loss of chiral integrity.
Reagent for: Synthesis of Aurora A kinase inhibitors, HPLC assay to determine D- and L- acid enantiomers in human plasma, Amide bond formation reactions.
Catalyst for: Selective acylation, Selecocyclization-oxidation deselenation sequence.
Synthesis
The synthesis of HATU is as follows:The resulting residue treated with 2-Methoxycarbonylamino-3-methyl-butyric acid (60 mg, 0.343 mmol) and HATU (130 mg, 0.343 mmol), suspended in DMF (3 mL) and cooled to 0° C. DIPEA (0.272 mL, 1.56 mmol) was added dropwise. After stirring for 4 h, NaOH (5M in H2O, 0.300 mL, 1.5 mmol) was added. This mixture was stirred for 3 h then diluted with EtOAc and washed with 1 M LiOH (2*) then brine. The organic phase was dried over MgSO4, filtered and concentrated. The crude residue was then purified by HPLC to afford the title compound (53 mg, 44%).
HATU Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5791 | 58 |
Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3000 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 +86-13986145403 | info@fortunachem.com | China | 5996 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 3001 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15957 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
Related articles
- The effect of HATU on human health
- HATU is reported to cause skin, eye, or respiratory irritation, and is denoted by an exclamation mark hazard symbol.
- Feb 10,2022
View Lastest Price from HATU manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-27 | HATU
148893-10-1
|
US $5.00 / kg | 1kg | 99.92% | 50000tons | Ouhuang Engineering Materials (Hubei) Co., Ltd | ||
2023-09-15 | HATU
148893-10-1
|
US $20.00 / g | 1g | 99.99% | 1000 KG | Lihe Pharm Technology(Wuhan)Co.,Ltd | ||
2023-08-05 | HATU
148893-10-1
|
US $100.00 / kg | 1kg | 99% | 1000tons | Henan Bao Enluo International TradeCo.,LTD |
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