ChemicalBook >> CAS DataBase List >>Cinchonine
Cinchonine
- CAS No.
- 118-10-5
- Chemical Name:
- Cinchonine
- Synonyms
- Cinchonin;(S)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol;D-CINCHONINE;NSC 6176;LA40221);CINCHONINE;Xin Kening;Xin Kenning;Cinchoninne;(+)-cinconine
- CBNumber:
- CB0244972
- Molecular Formula:
- C19H22N2O
- Molecular Weight:
- 294.39
- MDL Number:
- MFCD00064372
- MOL File:
- 118-10-5.mol
- MSDS File:
- SDS
Last updated:2024-04-25 13:42:50
| Melting point | 260-263 °C |
|---|---|
| alpha | 224 º (c=0.5, alcohol) |
| Boiling point | 436.16°C (rough estimate) |
| Density | 1.0863 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 223 ° (C=0.5, EtOH) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | 0.25g/l |
| form | Micro-Crystalline Powder |
| pka | 5.85, 9.92(at 25℃) |
| color | White to light beige |
| PH | 9.0 (0.25g/l, H2O, 20℃)(as aqueous solution) |
| optical activity | [α]23/D +228°, c = 0.5 in ethanol |
| Water Solubility | Insoluble |
| Sensitive | Light Sensitive |
| Merck | 14,2287 |
| BRN | 89689 |
| Stability | Stable, but may be light sensitive. Incompatible with strong oxidizing agents. |
| InChIKey | KMPWYEUPVWOPIM-QHQSXHFQSA-N |
| LogP | 2.82 at 25℃ |
| CAS DataBase Reference | 118-10-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | V43X79NZCD |
| NIST Chemistry Reference | Cinchonine(118-10-5) |
| EPA Substance Registry System | Cinchonan-9-ol, (9S)- (118-10-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317 | |||||||||
| Precautionary statements | P261-P264-P270-P280-P301+P312-P302+P352 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/22-20/21/22 | |||||||||
| Safety Statements | 26-36-36/37 | |||||||||
| RIDADR | 1544 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GD3500000 | |||||||||
| F | 8-34 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339900 | |||||||||
| Toxicity | LD50 i.p. in rats: 152 mg/kg (Johnson, Poe) | |||||||||
| NFPA 704 |
|
Cinchonine price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL80963 | (+)-Cinchonine phyproof? Reference Substance | 118-10-5 | 100MG | $262 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.02506 | (+)-Cinchonine for resolution of racemates for synthesis | 118-10-5 | 25g | $80 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.02506 | (+)-Cinchonine for resolution of racemates for synthesis | 118-10-5 | 100g | $237 | 2024-03-01 | Buy |
| Sigma-Aldrich | 27370 | Cinchonine crystallized, ≥98.0% (NT) | 118-10-5 | 25g | $62.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | 19431 | (+)-Cinchonine analytical standard | 118-10-5 | 50mg | $443 | 2022-05-15 | Buy |
Cinchonine Chemical Properties,Uses,Production
Description
Cinchonine is a cinchona alkaloid generally found in the bark of Cinchona officinalis plants. It is a pseudoenantiomer that is commonly employed in malaria therapy. Cinchonine is also used as an organocatalyst in many asymmetric reactions. It is a stereoisomer and pseudo-enantiomer of cinchonidine. It is structurally similar to quinine, an antimalarial drug.
Chemical Properties
white to light yellow crystal powde
Uses
Stereomeric with Cinchonidine (C441925). Antimalarial.
Uses
cardiotonic
Uses
Cinchonine occurs in most varieties of cinchonabark (Cinchona micrantha and Rubiaceae).It is used as an antimalarial agent.
Definition
ChEBI: Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (S configuration). It occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.
Health Hazard
The toxic effects from high doses of cinchonineinclude tinnitus, vomiting, diarrhea, andfever. The toxic effects noted in rats were excitement, change in motor activity, andconvulsions. An intraperitoneal LD50 valuein rats is 152 mg/kg.
Flammability and Explosibility
Non flammable
Purification Methods
Crystallise cinchonine from EtOH or diethyl ether. For the N-benzylcinchoninium chloride see above entry in this section. [Rabe Justus Liebigs Ann Chem 365 366, 371 1909, Beilstein 23 III/IV 2819, 2832.]
Cinchonine Preparation Products And Raw materials
Global( 406)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou TongYi biochemistry technology Co.,LTD | +8613073028829 | mack@tongyon.com | China | 2996 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12471 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 3001 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
View Lastest Price from Cinchonine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-25 | Cinchonine
118-10-5
|
US $15.00 / kg | 1kg | 99.912% | 10ton | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2023-07-04 | Cinchonine
118-10-5
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2022-05-11 | Cinchonine
118-10-5
|
US $0.00 / g | 10g | 99.0% | 10tons | Wuhan Godbullraw Chemical Co.,ltd |
-
- Cinchonine
118-10-5
- US $15.00 / kg
- 99.912%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- Cinchonine
118-10-5
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Cinchonine
118-10-5
- US $0.00 / g
- 99.0%
- Wuhan Godbullraw Chemical Co.,ltd
(+)-cinconine
(8r,9s)-cinchonine
(9s)-cinchonan-9-o
(9S)-Cinchonan-9-ol
(+)-CINCHONINE
CINCHONINE
CINCHONAN-9-OL,(9S)-
Cinchonine, 98+%
Cinchonine dihydrate monohydrochloride
Cinchonine Solution [for spray]
(9S)-Cinconan-9-ol
Cinchonine,99%
(+)-Cinchonine, 98+%, cont. up to 3% quinidine/dihydroquinidine and 3% quinine/dihydroquinine
Cinchonine ,98.5%
(5-Ethenyl-1-azabicyclo[2.2.2]oct-2-yl)(quinolin-4-yl)methanol
4-[(5-Ethenyl-1-azabicyclo[2.2.2]oct-2-yl)hydroxymethyl]quinoline
(S)-{5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl}(quinolin-4-yl)Methanol
Cinchonine, 99% 100GR
Cinchonine, 99% 25GR
(+)-Cinchonine, cont. up to 3% quinidine/dihydroquinidine and 3% quinine/dihydroquinine
Cinchonine, synthesis grade
NSC 6176
(+)-CINCHONINE FOR RESOLUTION OF RACEMAT
(1S)-Quinolin-4-yl((2R,4S,5R)-5-vinylquinuclidin-2-yl)Methanol
alpha-(5-vinyl-2-quinolyl)-2-quinuclidinemethano
alpha-4-quinolyl-5-vinyl-2-quinuclidinemethano
CINCHONINE FREE BASE
CINCHONINE, CRYSTALLIZED
CINCHONINE PURE
(+)-Quinolin-4-yl(5-vinylquinuclidin-2-yl)Methanol
Cinchonine (8CI)
Cinchonine (base and/or unspecified salts)
4-Quinolyl(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol
CINCHONINE:CINCHONAN-9-OL,(9S)-,
(+)-Cinchonine, 98+%, cont. up to 3% quinidine/dihydroquinidine and 3% quinine/dihydroquinidine
CINCHONINE(P)
CINCHONINE(RG)
homocinchonidine
homoquinidine
Cinchonine , 98.0%(T)
-Quinolin-4-yl(5-vinylquinuclidin-2-yl)
Cinchonine (Synonyms: (8R,9S)-Cinchonine
LA40221)
[5-ethenyl-4-(2-quinolinyl)-1-azabicyclo[2.2.2]octan-2-yl]methanol
Cinchonine(LA40221)
Cinchonine ((8R,9S)-Cinchonine
Xin Kenning
Xin Kening
Cinchonine >
(S)-Quinolin-4-yl((1S,2R,4S,5S)-5-vinylquinuclidin-2-yl)methanol
Quinidine EP Impurity B
4-QUINOLYL(5-VINYL-1-AZABICYCLO[2.2.2]OCT-2-YL)MET
Cinchonine USP/EP/BP
[(5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-quinolin-4-ylmethanol
CINCHONINE For Synthesis
UNII-WTV8EPZ396
D-CINCHONINE
Cinchonin