4-amino-2-fluoro-N-methylbenzamide
- CAS No.
- 915087-25-1
- Chemical Name:
- 4-amino-2-fluoro-N-methylbenzamide
- Synonyms
- N-Methyl-2-fluoro-4-aminobenzamide;N-Methyl-4-amino-2-fluoro-benzamide;Enzalutamide ITS-3;Enzalutamide Impurity 20;Enzalutamide Impurity 40;4-AMINO-2-FLUORO-N-METHYLBENZAMIDE;4-amino-2-fluoro-N-menthylbenzamide;N-Methyl-2-fluoro-4-AminobenzoylAmine;2. 4-aMino-2-fluoro-N-MethylbenzaMide;BenzaMide, 4-aMino-2-fluoro-N-Methyl-
- CBNumber:
- CB02452656
- Molecular Formula:
- C8H9FN2O
- Molecular Weight:
- 168.17
- MDL Number:
- MFCD09909322
- MOL File:
- 915087-25-1.mol
- MSDS File:
- SDS
Melting point | 160 - 163°C |
---|---|
Boiling point | 320℃ |
Density | 1.234 |
Flash point | 147℃ |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
pka | 14.12±0.46(Predicted) |
color | White to Off-White |
Stability | Moisture Sensitive |
InChI | InChI=1S/C8H9FN2O/c1-11-8(12)6-3-2-5(10)4-7(6)9/h2-4H,10H2,1H3,(H,11,12) |
InChIKey | XOKAXPQJUODMSH-UHFFFAOYSA-N |
SMILES | C(NC)(=O)C1=CC=C(N)C=C1F |
FDA UNII | Y2H4HB3FQL |
SAFETY
Risk and Safety Statements
Signal word | Warning |
---|---|
Hazard statements | H317-H319-H302 |
Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
HS Code | 2924297099 |
4-amino-2-fluoro-N-methylbenzamide price More Price(21)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | A609743 | 4-Amino-2-fluoro-N-methylbenzamide | 915087-25-1 | 25g | $275 | 2021-12-16 | Buy |
TRC | A609743 | 4-Amino-2-fluoro-N-methylbenzamide | 915087-25-1 | 50g | $520 | 2021-12-16 | Buy |
AK Scientific | J95296 | 4-Amino-2-fluoro-N-methylbenzamide | 915087-25-1 | 100g | $520 | 2021-12-16 | Buy |
Matrix Scientific | 143913 | 4-Amino-2-fluoro-N-methylbenzamide 95% | 915087-25-1 | 25g | $1110 | 2021-12-16 | Buy |
Matrix Scientific | 143913 | 4-Amino-2-fluoro-N-methylbenzamide 95% | 915087-25-1 | 5g | $370 | 2021-12-16 | Buy |
4-amino-2-fluoro-N-methylbenzamide Chemical Properties,Uses,Production
Uses
4-amino-2-fluoro-N-methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors.
Description
4-amino-2-fluoro-N-methylbenzamide is a novel antiandrogen drug MDV (Marek's Disease Virus) 3100 key intermediate which is the new generation oral androgen antagonist medicine of united states drug developer Medivation company exploitation, be mainly used in treating advanced prostate cancer (CRPC) patient.
Preparation
2-fluoro-4-nitrotoluene as raw material, through potassium permanganate oxidation, the thionyl chloride chlorination, methylamine amination, and Pd/C hydrogenation reduction prepare 4-amino-2-fluoro-N-methylbenzamide.
4-amino-2-fluoro-N-methylbenzamide Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Porton Pharma Solutions Ltd. | China | 56 | 58 | ||
Shanghai Joiny Pharmaceutical Co.,LTD | +8613681955282 | gyd@joiny-pharma.com | China | 228 | 58 |
Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 +86-13176845580 | da@zhongda-biotech.com | China | 248 | 58 |
Anhui Zhongda Biotechnology Co., Ltd | +8615689548120 | linda@zhongda-biotech.com | China | 204 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15957 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
Shandonghaohong biotechnology Co.,ltd. | 0635-6175299 13961496334 | sale@inyelchem.com | CHINA | 44 | 55 |
View Lastest Price from 4-amino-2-fluoro-N-methylbenzamide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-05-15 | 4-AMINO-2-FLUORO-N-METHYLBENZAMIDE
915087-25-1
|
US $9.90-454.00 / g | 1g | 99% | 100kg | Wuhan Cell Pharmaceutical Co., Ltd | ||
2024-04-30 | N-Methyl-2-fluoro-4-aminobenzamide
915087-25-1
|
US $15.00-50.00 / kg | 1kg | NLT98% | 5 ton per month | Anhui Dexinjia Biopharm Co., Ltd | ||
2024-04-10 | N-Methyl-2-fluoro-4-aminobenzamide
915087-25-1
|
US $0.00 / kg | 1kg | 98% | 5500kg | Shanghai Joiny Pharmaceutical Co.,LTD |
- 4-AMINO-2-FLUORO-N-METHYLBENZAMIDE
915087-25-1
- US $9.90-454.00 / g
- 99%
- Wuhan Cell Pharmaceutical Co., Ltd
- N-Methyl-2-fluoro-4-aminobenzamide
915087-25-1
- US $15.00-50.00 / kg
- NLT98%
- Anhui Dexinjia Biopharm Co., Ltd
- N-Methyl-2-fluoro-4-aminobenzamide
915087-25-1
- US $0.00 / kg
- 98%
- Shanghai Joiny Pharmaceutical Co.,LTD
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