ChemicalBook >> CAS DataBase List >>BAY-1143572.
BAY-1143572.
- CAS No.
- 1414943-88-6
- Chemical Name:
- BAY-1143572.
- Synonyms
- BAY1143572;BAY 1143572;BAY-1143572.;Atuveciclib Racemate;BAY-1143572 Racemate;Atuveciclib(BAY-1143572);ATUVECICLIB RACEMATE (BAY-1143572 RACEMATE);4-(4-fluoro-2-methoxyphenyl)-N-(3-((S-methylsulfonimidoyl)methyl)phenyl)-1,3,5-triazin-2-amine;1,3,5-Triazin-2-amine, 4-(4-fluoro-2-methoxyphenyl)-N-[3-[(S-methylsulfonimidoyl)methyl]phenyl]-;(rac)-4-(4-fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine
- CBNumber:
- CB03133468
- Molecular Formula:
- C18H18FN5O2S
- Molecular Weight:
- 387.43
- MDL Number:
- MOL File:
- 1414943-88-6.mol
Last updated:2023-05-21 10:59:17
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
BAY-1143572. price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-6307 | AtuveciclibRacemate 98.48% | 1414943-88-6 | 5mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-6307 | AtuveciclibRacemate 98.48% | 1414943-88-6 | 10mg | $850 | 2021-12-16 | Buy |
| DC Chemicals | DC10376 | BAY-1143572 >98% | 1414943-88-6 | 100mg | $950 | 2021-12-16 | Buy |
BAY-1143572. Chemical Properties,Uses,Production
Biological Activity
Atuveciclib (BAY-1143572) is a potent and highly selective PTEFb/CDK9 inhibitor with IC50 of 13 nM for CDK9/CycT. Its IC50 for CDK2 is about 100-fold higher than that for CDK9. In addition to CDK family members, it also inhibits GSK3 kinase with IC50 values of 45 nM and 87 nM for GSK3α and GSK3β, respectively.
in vivo
BAY 1143572 has a low plasma clearance (CL b 1.1 L/h/kg) and a volume of distribution (Vss) of 1.0 L/kg in a rat pharmacokinetic study . Its oral bioavailability is 54% and the blood-plasma concentration ratio is 1. BAY 1143572 has no significant inhibitory effect on cytochrome P450 activity, IC50>20 μM. NOD/Shi-scid/IL-2Rγ in immunocompromised.
target
| Target | Value |
| CDK9 (Cell-free assay) | 13 nM |
| GSK-3α () | 45 nM |
| GSK3β () | 87 nM |
BAY-1143572. Preparation Products And Raw materials
Raw materials
Preparation Products
BAY-1143572. Suppliers
Global( 48)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3582 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +8618168183658 | sales1@artkmedchem.com | China | 39009 | 58 |
| Jiangsu shring Biopharma Co., Ltd. | +8613372282299 | sales@shringchem.com | China | 3545 | 58 |
BAY 1143572
BAY1143572
BAY-1143572.
ATUVECICLIB RACEMATE (BAY-1143572 RACEMATE)
Atuveciclib Racemate
Atuveciclib(BAY-1143572)
(rac)-4-(4-fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine
4-(4-fluoro-2-methoxyphenyl)-N-(3-((S-methylsulfonimidoyl)methyl)phenyl)-1,3,5-triazin-2-amine
BAY-1143572 Racemate
1,3,5-Triazin-2-amine, 4-(4-fluoro-2-methoxyphenyl)-N-[3-[(S-methylsulfonimidoyl)methyl]phenyl]-
Atuveciclib,BAY1143572,Cyclin dependent kinase,inhibit,Inhibitor,CDK,Atuveciclib Racemate,BAY 1143572,BAY-1143572
1414943-88-6