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ChemicalBook >> CAS DataBase List >>Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-[[5-(trifluoromethyl)-2-furanyl]methyl]-, (3'R)-

Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-[[5-(trifluoromethyl)-2-furanyl]methyl]-, (3'R)-

Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-[[5-(trifluoromethyl)-2-furanyl]methyl]-, (3'R)- Structure
Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-[[5-(trifluoromethyl)-2-furanyl]methyl]-, (3'R)- structure
CAS No.
1259933-15-7
Chemical Name:
Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-[[5-(trifluoromethyl)-2-furanyl]methyl]-, (3'R)-
Synonyms
(R)-Funapide;Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-[[5-(trifluoromethyl)-2-furanyl]methyl]-, (3'R)-
CBNumber:
CB05562426
Molecular Formula:
C22H14F3NO5
Molecular Weight:
429.35
MDL Number:
MOL File:
1259933-15-7.mol
Last updated:2023-05-21 10:59:17
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Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-[[5-(trifluoromethyl)-2-furanyl]methyl]-, (3'R)- Properties

storage temp. Store at -20°C
solubility DMSO : 220 mg/mL (512.40 mM; Need ultrasonic)

Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-[[5-(trifluoromethyl)-2-furanyl]methyl]-, (3'R)- Chemical Properties,Uses,Production

Biological Activity

(R)-Funapide ((R)-TV 45070) is the less active R-enantiomer of Funapide. Funapide is a potent Nav1.7 sodium channel blocker that can be used for pain research[1].

References

[1]. Sharan K Bagal, et al. Recent progress in sodium channel modulators for pain. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3690-9.

Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-[[5-(trifluoromethyl)-2-furanyl]methyl]-, (3'R)- Preparation Products And Raw materials

Raw materials

Preparation Products

Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-[[5-(trifluoromethyl)-2-furanyl]methyl]-, (3'R)- Suppliers

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Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
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Aladdin Scientific 		58
Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-[[5-(trifluoromethyl)-2-furanyl]methyl]-, (3'R)- (R)-Funapide 1259933-15-7