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ChemicalBook >> CAS DataBase List >>2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID

2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID

2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID Structure
2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID structure
CAS No.
292870-53-2
Chemical Name:
2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID
Synonyms
BV02;TOSLAB 796846;BV02 >=98% (HPLC);2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID;2-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2,3-dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid;2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid;1H-Isoindole-5-carboxylic acid, 2-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2,3-dihydro-1,3-dioxo-
CBNumber:
CB0712242
Molecular Formula:
C20H15N3O5
Molecular Weight:
377.35
MDL Number:
MFCD00356631
MOL File:
Mol file
MSDS File:
SDS
Last updated:2023-09-04 15:51:00
Request For Quotation

2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID Properties

Boiling point 593.8±60.0 °C(Predicted)
Density 1.512±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: >5mg/mL
pka 3.39±0.20(Predicted)
form powder
color white to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS09
Signal word  Warning
Hazard statements  H400
Precautionary statements  P273
Hazard Codes  N
Risk Statements  50
Safety Statements  61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3

2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0140 BV02 ≥98% (HPLC) 292870-53-2 5mg $120 2024-03-01 Buy
Sigma-Aldrich SML0140 BV02 ≥98% (HPLC) 292870-53-2 25mg $467 2024-03-01 Buy
Product number Packaging Price Buy
SML0140 5mg $120 Buy
SML0140 25mg $467 Buy

2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID Chemical Properties,Uses,Production

Uses

BV02 has been used to study the effects of 14-3-3σ on P-glycoprotein and pregnane X receptor protein xpression. It has also been used as a control in studying BAP1 (BRCA1 (breast cancer gene)-associated protein 1) inducing cell death via interaction with 14-3-3 in neuroblastoma.

Biochem/physiol Actions

BV02 is an inhibitor of the 14-3-3 scaffolding proteins docking site. BV02 promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation. It induces apoptosis by c-Abl release from 14-3-3? and re-location to nuclear compartment and at mitochondrial membranes.

2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID synthesis

83-07-8
552-30-7
292870-53-2
Synthesis of 2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID from 4-Aminoantipyrine and Trimellitic Anhydride

2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID Suppliers

Global( 16)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai Beckham Medical Technology Co., Ltd 021-13816613772 13816613772 huahero21@sina.com China 358 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8012 62
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8618 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24024 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 5019 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9180 58
Supplier Advantage
Aladdin Scientific 		58
Sigma-Aldrich 80
Shanghai Beckham Medical Technology Co., Ltd 55
Shanghai EFE Biological Technology Co., Ltd. 58
ShangHai Biochempartner Co.,Ltd 62
Energy Chemical 58
Changzhou Furuisi Biotechnology Co., Ltd 58
TargetMol Chemicals Inc. 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
RD International Technology Co., Limited 58

2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID Spectrum

2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID(292870-53-2)1HNMR
TOSLAB 796846 2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID 2-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2,3-dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid BV02 2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid BV02 >=98% (HPLC) 1H-Isoindole-5-carboxylic acid, 2-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2,3-dihydro-1,3-dioxo- 292870-53-2