4-(Trifluoromethyl)nicotinic acid
- CAS No.
- 158063-66-2
- Chemical Name:
- 4-(Trifluoromethyl)nicotinic acid
- Synonyms
- TFNA;4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXYLIC ACID;TFNA Standard;BUTTPARK 43\57-42;RARECHEM AL BO 0760;TFNA (flonicamid metabolite);4-(Trifluromethyl)nicotinic acid;-(Trifluoromethyl)nicotinic acid;4-(TRIFLUOROMETHYL)NICOTINIC ACID;4-(Trifluoromethyl)nicotinicacid98%
- CBNumber:
- CB0722311
- Molecular Formula:
- C7H4F3NO2
- Molecular Weight:
- 191.11
- MDL Number:
- MFCD00082626
- MOL File:
- 158063-66-2.mol
- MSDS File:
- SDS
| Melting point | 146-148 °C(lit.) |
|---|---|
| Boiling point | 290.4±40.0 °C(Predicted) |
| Density | 1.484±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 2.50±0.36(Predicted) |
| form | Solid |
| color | Pale Yellow to Dark Yellow |
| InChIKey | LMRJHNFECNKDKH-UHFFFAOYSA-N |
| CAS DataBase Reference | 158063-66-2(CAS DataBase Reference) |
| FDA UNII | 04F679X18B |
| EPA Substance Registry System | 3-Pyridinecarboxylic acid, 4-(trifluoromethyl)- (158063-66-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
4-(Trifluoromethyl)nicotinic acid price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 518697 | 4-(Trifluoromethyl)pyridine-3-carboxylic acid 98% | 158063-66-2 | 1g | $74.1 | 2024-03-01 | Buy |
| TCI Chemical | T2742 | 4-(Trifluoromethyl)nicotinic Acid | 158063-66-2 | 1G | $45 | 2024-03-01 | Buy |
| TCI Chemical | T2742 | 4-(Trifluoromethyl)nicotinic Acid | 158063-66-2 | 5G | $177 | 2024-03-01 | Buy |
| Alfa Aesar | L19553 | 4-(Trifluoromethyl)nicotinic acid, 98% | 158063-66-2 | 250mg | $68.65 | 2024-03-01 | Buy |
| Alfa Aesar | L19553 | 4-(Trifluoromethyl)nicotinic acid, 98% | 158063-66-2 | 1g | $126.65 | 2024-03-01 | Buy |
4-(Trifluoromethyl)nicotinic acid Chemical Properties,Uses,Production
Uses
4-(Trifluoromethyl)-3-Pyridinecarboxylic Acid is a useful synthetic intermediate. It can be used to prepare pyridine carboxamides as palm site inhibitors of HCV NS5B polymerase. It can also be used to synthesize pyrazolylcarboxanilides as Ca2+ release-activated Ca2+ (CRAC) channel inhibitors.
Application
4-(Trifluoromethyl)nicotinic acid is a trifluoromethyl-containing aromatic compound with unique biological activity, which can be used as a precursor material for the preparation of other pesticides or medicines. 4-(Trifluoromethyl)nicotinic acid is a key intermediate of flonicamid, a highly effective insecticide.
Preparation
synthesis of 4-(Trifluoromethyl)nicotinic acid: add 5g (0.0192mol) Methyl 2,6-dichloro-4-(trifluoromethyl)nicotinate in turn to a 100mL three-necked flask, 0.3g of 10% Pd/C (water content 63.45%) ), 5.25g (0.0389mol) CH3COONa 3H2O and 20mL ethanol, after stirring and dissolving, nitrogen was replaced 3 times to discharge air, after hydrogen replacement 2 times, the reaction was stirred at room temperature for 8h under a hydrogen atmosphere until no hydrogen was absorbed to complete the reaction, and suction filtration was recovered. Palladium carbon, washed the filter cake 3 times with ethanol, the filtrate was rotary evaporated to remove the solvent, added 20 mL of water to the obtained solid, fully shaken to dissolve it, added hydrochloric acid to adjust pH=2～3, extracted 3 times with ethyl acetate, The organic phases were combined and washed three times with saturated brine, dried over anhydrous sodium sulfate, and rotary-evaporated to obtain 3.3 g of a pale yellow solid with a yield of 90.4%.
Definition
ChEBI: 4-(trifluoromethyl)nicotinic acid is a member of pyridines and an aromatic carboxylic acid.
4-(Trifluoromethyl)nicotinic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12471 | 58 |
| PNP Biotech Co. Ltd | +8618516098983 | sales@pnpbiotech.com | China | 1001 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 3001 | 58 |
| Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 | info@spring-chem.com | China | 2068 | 57 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15957 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
View Lastest Price from 4-(Trifluoromethyl)nicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-23 | 4-(Trifluoromethyl)nicotinic acid
158063-66-2
|
US $50.00 / kg | 1kg | 99.10% | 50000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2024-03-28 | 4-(Trifluoromethyl)nicotinic acid
158063-66-2
|
US $0.00 / kg | 25kg | 98% | Inquiry | PNP Biotech Co. Ltd | |
 |
2023-11-13 | 4-(Trifluoromethyl)nicotinic acid
158063-66-2
|
US $0.00 / Kg/Drum | 1Kg/Drum | 98% | 100tons | Wuhan Boye Science And Technology Development Co., Ltd. |
-
- 4-(Trifluoromethyl)nicotinic acid
158063-66-2
- US $50.00 / kg
- 99.10%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- 4-(Trifluoromethyl)nicotinic acid
158063-66-2
- US $0.00 / kg
- 98%
- PNP Biotech Co. Ltd
-
- 4-(Trifluoromethyl)nicotinic acid
158063-66-2
- US $0.00 / Kg/Drum
- 98%
- Wuhan Boye Science And Technology Development Co., Ltd.
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