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Sitagliptin phosphate monohydrate

Sitagliptin phosphate monohydrate structure

CAS No.: 654671-77-9

Chemical Name:: Sitagliptin phosphate monohydrate

Synonyms: Sitagliptin phosphate hydrate;Sitagliptin monohydrate;(R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate monohydrate;Sitagliptin Phosphate.H2O;(R)-3-Amino-1-(3-(trifluor;itagliptin phosphate monohydrate;(R)-3-AMino-1-(3-(trifluoroMethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate hydrate;7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)Butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazinephosphatemonohydrate;7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate (1:1) monohydrate;D06645

CBNumber:: CB11011754

Molecular Formula:: C16H18F6N5O5P

Molecular Weight:: 505.31

MDL Number:: MFCD10001393

MOL File:: 654671-77-9.mol

Last updated:2024-05-15 13:17:26

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Sitagliptin phosphate monohydrate Properties

Flash point	274.3℃
storage temp.	2-8°C
solubility	≥23.8 mg/mL in DMSO; insoluble in EtOH; ≥30.6 mg/mL in H2O with ultrasonic
form	solid
CAS DataBase Reference	654671-77-9(CAS DataBase Reference)
FDA UNII	TS63EW8X6F

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Warning
Hazard statements	H319-H373
Precautionary statements	P260-P264-P280-P305+P351+P338-P314-P337+P313
Risk Statements	28-38-41-48-62-63
Safety Statements	24/25-26-28-36/37/39
HS Code	29335990

Sitagliptin phosphate monohydrate price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR1857	Sitagliptin Phosphate Pharmaceutical Secondary Standard; Certified Reference Material	654671-77-9	1g	$173	2024-03-01	Buy
Sigma-Aldrich	1612903	Sitagliptin phosphate United States Pharmacopeia (USP) Reference Standard	654671-77-9	200mg	$436	2024-03-01	Buy
Sigma-Aldrich	Y0001812	Sitagliptin phosphate monohydrate EuropePharmacopoeia (EP) Reference Standard	654671-77-9	y0001812	$220	2024-03-01	Buy
American Custom Chemicals Corporation	API0000800	SITAGLIPTIN PHOSPHATE MONOHYDRATE 95.00%	654671-77-9	1G	$918.23	2021-12-16	Buy
American Custom Chemicals Corporation	API0000800	SITAGLIPTIN PHOSPHATE MONOHYDRATE 95.00%	654671-77-9	5G	$2246.48	2021-12-16	Buy

Product number	Packaging	Price	Buy
PHR1857	1g	$173	Buy
1612903	200mg	$436	Buy
Y0001812	y0001812	$220	Buy
API0000800	1G	$918.23	Buy
API0000800	5G	$2246.48	Buy

Sitagliptin phosphate monohydrate Chemical Properties,Uses,Production

Chemical Properties

white crystalline

Uses

antimuscarinic

Uses

Sitagliptin Phosphate Monohydrate is a dipeptidyl peptidase-IV (DPPIV) inhibitor.

Biological Activity

sitagliptin phosphate monohydrate is the phosphate salt of its active component, sitagliptin, with one molecule of water. sitagliptin is a potent inhibitor of dipeptidyl peptidase 4 (dpp-4), an enzyme catalyzing the cleavage of peptides with an n-terminal alanine or proline amino acid residue, that selectively inhibits dpp-4 with 50% inhibition concentration ic50 value of 18 nm and shows no affinity towards other ddp enzymes (such as ddp-8 and ddp-9). the inhibition of dpp4 by sitagliptin has been found to be mediated by increasing levels of two dpp-4 substrates, including glucagon-like peptide-1 (glp-1) and gastric inhibitory polypeptide (gip). sitagliptin is currently being investigated in the treatment of type ii diabetes.gallwitz b. review of sitagliptin phosphate: a novel treatment for type 2 diabetes. vasc health risk manag. 2007;3(2):203-10.

target

DPP-4

Sitagliptin phosphate monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Sitagliptin phosphate monohydrate Suppliers

Global( 536)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	6000	58
shandong perfect biotechnology co.ltd	+86-53169958659; +8618596095638	sales@sdperfect.com	China	294	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-18580541567 +86-17782035140	sales@zhswyy.com	China	242	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	18232	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	811	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
shandong perfect biotechnology co.ltd	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Hi-Tech Chemistry Corp	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60

View Lastest Price from Sitagliptin phosphate monohydrate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-05-16	Sitagliptin phosphate monohydrate 654671-77-9	US $0.00 / kg	1kg	98% HPLC	1000 kgs	PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
2024-05-11	Sitagliptin phosphate monohydrate 654671-77-9	US $0.00-0.00 / kg	0.10000000149011612kg	99	20tons	Chongqing Zhihe Biopharmaceutical Co., Ltd.
2024-05-09	Sitagliptin phosphate monohydrate 654671-77-9	US $0.00-0.00 / kg	1kg	99%, Single impurity＜0.1	1 ton	Nanjing Fred Technology Co., Ltd

Sitagliptin phosphate monohydrate
654671-77-9
US $0.00 / kg
98% HPLC
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD

Sitagliptin phosphate monohydrate
654671-77-9
US $0.00-0.00 / kg
99
Chongqing Zhihe Biopharmaceutical Co., Ltd.

Sitagliptin phosphate monohydrate
654671-77-9
US $0.00-0.00 / kg
99%, Single impurity＜0.1
Nanjing Fred Technology Co., Ltd

Sitagliptin phosphate monohydrate Spectrum

Sitagliptin phosphate monohydrate(654671-77-9)¹HNMR

654671-77-9(Sitagliptin phosphate monohydrate)Related Search:

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1of4

Sitagliptin phosphate monohydrate 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate monohydrate Sitagliptin phosphate mon Sitagliptin phosphate monohydrate, >=99% (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4 Sitagliptin phosphate monohydrate Sitagliptin phosphate for research D06645 Januvia (tn) Sitagliptin phosphate (usan) Sitagliptin phosphate hydrate (jan) Sitagliptin Monophosphate Monohydrate Sitaglipin Phosphate Monohydrate Sitagliptin phosphate monohydrate 99% sitagpliptin monohydrate (2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine Dihydrogen Phosphate Monohydrate Sitagliptin phosephate monohydrate Sitagliptin posphate monohydrate Sitagliptin phosphate monohydrate, 97%, DPP-IV inhibitor MK-0431 PHOSPHATE MONOHYDRATE Sitagliptin phosphate monohydrate CRS Creatinine, Uric acid, Urea, Glucose Siglitatin phosphate 1,2,4-Triazolo[4,3-a]pyrazine,7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-, phosphate (1:1), monohydrate Sitagliptin phosphate monohydrate USP/EP/BP Sitagliptin Phosphate Monohydrate Please see S491000 Sitagliptin phosphate monohydrate (API) Manufacturer Supplying High Quality Sitagliptin Phosphate Monohydrate API with CAS 654671-77-9 Sitagliptin phosphate (Monohydrate)Q: What is Sitagliptin phosphate (Monohydrate) Q: What is the CAS Number of Sitagliptin phosphate (Monohydrate) Q: What is the storage condition of Sitagliptin phosphate (Monohydrate) Sitagliptin Phosphate (1612903) 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)Butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazinephosphatemonohydrate 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate (1:1) monohydrate Sitagliptin phosphate hydrate Sitagliptin monohydrate Sitagliptin Phosphate.H2O (R)-3-AMino-1-(3-(trifluoroMethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate hydrate (R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate monohydrate (R)-3-Amino-1-(3-(trifluor itagliptin phosphate monohydrate SIT-12 (R)-Sitaglipin Phosphate Monohydrate 1-Octen-3-ol 3391-86-4 Sitagliptin Impurity 20 Phosphate Monohydrate SITAGLIPTIN PHOSAPHATE MONOHYDRATE-IP Sitagliptin Impurity 15 Phosphate Monohydrate Sitagliptin Phosphate Monohydrate-IP /USP/BP 654671-77-9 C16H20F6N5O6P C16H15F6N5OH3PO4H2O C16H15F6N5OH3O4PH2O C16H15F6N5OH2OH3O4P Inhibitors Inhibitor API APIs 654671-77-9