A 286982
- CAS No.
- 280749-17-9
- Chemical Name:
- A 286982
- Synonyms
- A 286982;A 286982,Integrin,allosteric,LFA-1,A286982,Inhibitor,A-286982,inhibit,ICAM-1;(2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one;2-Propen-1-one, 1-(4-acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-, (2E)-
- CBNumber:
- CB12538269
- Molecular Formula:
- C24H27N3O4S
- Molecular Weight:
- 453.55
- MDL Number:
- MFCD19690958
- MOL File:
- 280749-17-9.mol
- MSDS File:
- SDS
| storage temp. | -20°C |
|---|---|
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| color | white to beige |
| FDA UNII | 5I8WFS075A |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| WGK Germany | 3 |
A 286982 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0595 | A-286982 ≥95% (HPLC) | 280749-17-9 | 5mg | $119 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0595 | A-286982 ≥95% (HPLC) | 280749-17-9 | 25mg | $428 | 2022-05-15 | Buy |
| Cayman Chemical | 27646 | A286982 | 280749-17-9 | 5mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 27646 | A286982 | 280749-17-9 | 50mg | $577 | 2024-03-01 | Buy |
| Cayman Chemical | 27646 | A286982 | 280749-17-9 | 10mg | $155 | 2024-03-01 | Buy |
A 286982 Chemical Properties,Uses,Production
Description
A286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1; IC50 = 35 nM). It inhibits adhesion of JY-8 cells to ICAM-1-coated microtiter plates (IC50 = 44 nM).
Uses
A 286982 is a potent lymphocyte function-associated antigen-1 (LFA-1) and intracellular adhesion mol.-1 (ICAM-1) interaction inhibitor.
storage
Store at RT
References
[1]. liu, g., et al., discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. identification of an additional binding pocket based on an anilino diaryl sulfide lead. j med chem, 2000. 43(21): p. 4025-40.
[2]. katakai, t., k. habiro, and t. kinashi, dendritic cells regulate high-speed interstitial t cell migration in the lymph node via lfa-1/icam-1. j immunol, 2013. 191(3): p. 1188-99.
[3]. keating, s.m., et al., competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1. protein sci, 2006. 15(2): p. 290-303.
A 286982 Preparation Products And Raw materials
Raw materials
Preparation Products
A 286982 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4398 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 |