Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>(±)14(15)-EET-SI

(±)14(15)-EET-SI

(±)14(15)-EET-SI Structure
(±)14(15)-EET-SI structure
CAS No.
218461-97-3
Chemical Name:
(±)14(15)-EET-SI
Synonyms
(±)14(15)-EET-SI;5,8,11-Tridecatrienamide, N-(methylsulfonyl)-13-(3-pentyl-2-oxiranyl)-, (5Z,8Z,11Z)-
CBNumber:
CB12589791
Molecular Formula:
C21H35NO4S
Molecular Weight:
397.57
MDL Number:
MFCD12912332
MOL File:
218461-97-3.mol
Last updated:2023-06-08 09:03:08
Request For Quotation

(±)14(15)-EET-SI Properties

Density 1.060±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
pka 4.63±0.40(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H302-H319-H336
Precautionary statements  P210-P240-P241-P242-P243-P261-P264-P270-P271-P280-P301+P312-P330-P303+P361+P353-P304+P340-P305+P351+P338-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
NFPA 704
3
2 0

(±)14(15)-EET-SI price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10009286 (±)14(15)-EET-SI ≥95% 218461-97-3 25μg $81 2024-03-01 Buy
Cayman Chemical 10009286 (±)14(15)-EET-SI ≥95% 218461-97-3 50μg $152 2024-03-01 Buy
Cayman Chemical 10009286 (±)14(15)-EET-SI ≥95% 218461-97-3 100μg $286 2024-03-01 Buy
American Custom Chemicals Corporation LIP0000668 N-(METHYLSULFONYL)-13-(3-PENTYLOXIRANYL)-5Z,8Z,11Z-TRIDECATRIENAMIDE 95.00% 218461-97-3 5MG $496.39 2021-12-16 Buy
Product number Packaging Price Buy
10009286 25μg $81 Buy
10009286 50μg $152 Buy
10009286 100μg $286 Buy
LIP0000668 5MG $496.39 Buy

(±)14(15)-EET-SI Chemical Properties,Uses,Production

Description

Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes. The EETs are released in response to acetylcholine, bradykinin, arachidonic acid, or cyclic stretch.1 (±)14(15)-EET-SI is the methyl sulfonamide analog of 14(15)-EET. This substitution results in a metabolically more stable compound because it is not sensitive to β-oxidation or membrane esterification. (±)14(15)-EET-SI is equipotent to 14(15)-EET in vascular agonist activity as measured by relaxation of precontracted bovine coronary arteries.1 In addition, 14(15)-EET and the methyl sulfonamide analog both stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells.2

References

1. Gauthier, K.M., Falck, J.R., Reddy, L.M., et al. 14,15-EET analogs: Characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries Pharmacol. Res. 49(6),515-524(2004).
2. Chen, J.K., Falck, J.R., Reddy, K.M., et al. Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells J. Biol. Chem. 273(44),29254-29261(1998).

(±)14(15)-EET-SI Preparation Products And Raw materials

Raw materials

Preparation Products

(±)14(15)-EET-SI Suppliers

Global( 13)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.com China 24246 58
Supplier Advantage
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58
TargetMol Chemicals Inc. 58
(±)14(15)-EET-SI 5,8,11-Tridecatrienamide, N-(methylsulfonyl)-13-(3-pentyl-2-oxiranyl)-, (5Z,8Z,11Z)- 218461-97-3