EPPTB
- CAS No.
- 1110781-88-8
- Chemical Name:
- EPPTB
- Synonyms
- EPPTB;RO5212773);Ro 5212773 (EPPTB);EPPTB (RO 5212773;N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide;N-(3-Ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)benzamide;Benzamide, N-(3-ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)-;Ro-5212773,Inhibitor,Ro 5212773,neuronal,inhibit,Ro5212773,mesolimbic,system,TAAR1,GPCR
- CBNumber:
- CB13146292
- Molecular Formula:
- C20H21F3N2O2
- Molecular Weight:
- 378.39
- MDL Number:
- MFCD21605509
- MOL File:
- 1110781-88-8.mol
EPPTB price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1350 | EPPTB ≥95% (HPLC) | 1110781-88-8 | 5MG | $100 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1350 | EPPTB ≥95% (HPLC) | 1110781-88-8 | 25MG | $393 | 2024-03-01 | Buy |
| Tocris | 4518 | EPPTB ≥99%(HPLC) | 1110781-88-8 | 10 | $168 | 2021-12-16 | Buy |
| Tocris | 4518 | EPPTB ≥99%(HPLC) | 1110781-88-8 | 50 | $699 | 2021-12-16 | Buy |
| Usbiological | 255257 | EPPTB | 1110781-88-8 | 10mg | $409 | 2021-12-16 | Buy |
EPPTB Chemical Properties,Uses,Production
Description
EPPTB (1110781-88-8) is a novel selective trace amine associated receptor 1 (TAAR1) antagonist (IC50=28 nM at mouse TAAR1).1,2 A useful tool for probing the physiologic role of TAAR1.3-6
Uses
EPPTB is a selective antagonist of the trace amine-associated 1 (TA1) receptor, increasing the firing frequency of dopamine (DA) neurons in the ventral tegmental area. This makes it a promising drug target for neurodegenerative disorders.
storage
Store at +4°C
References
1) Bradaia et al. (2009), The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system; Proc. Natl. Acad. Sci. USA, 106 20081 2) Stalder et al. (2011), Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): discovery of EPPTB (RO5212773); Bioorg. Med. Chem. Lett., 21 1227 3) Zhang et al. (2018), Striatal Tyrosine Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine; Front. Pharmacol., 9 166 4) De Greggrio et al. (2016), The hallucinogen d-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT1A, D2 and TAAR1 receptors; Pharmacol. Res., 113 81 5) Cichero et al. (2014), Further insights into the pharmacology of the human trace amine-associated receptors: discovery of the novel ligands for TAAR1 by a virtual screening approach; Chem. Biol. Drug Des., 84 712 6) Liu et al. (2014), Ractopamine, a livestock feed additive, is a full agonist at trace amine-associated receptor 1; J. Pharmacol. Exp. Ther. 350 124
EPPTB Preparation Products And Raw materials
Raw materials
Preparation Products
EPPTB Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3445 | 55 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9747 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 879 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |