ChemicalBook >> CAS DataBase List >>ARV-771
ARV-771
- CAS No.
- 1949837-12-0
- Chemical Name:
- ARV-771
- Synonyms
- ARV-771;ARV 771; ARV771;Epigenetic Reader Domain,ARV-771,ARV771,inhibit,ARV 771,PROTACs,Inhibitor;(2S,4R)-1-[(2S)-2-[[2-[3-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-;(2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-2-[[2-[3-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
- CBNumber:
- CB13167639
- Molecular Formula:
- C49H60ClN9O7S2
- Molecular Weight:
- 986.65
- MDL Number:
- MFCD30738017
- MOL File:
- 1949837-12-0.mol
Last updated:2024-04-18 17:30:06
| Density | 1.39±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility |
DMSO:65.92(Max Conc. mg/mL);68.22(Max Conc. mM) DMF:20.0(Max Conc. mg/mL);20.7(Max Conc. mM) DMF:PBS (pH 7.2) (1:6):0.14(Max Conc. mg/mL);0.14(Max Conc. mM) Ethanol:55.0(Max Conc. mg/mL);56.92(Max Conc. mM) |
| form | A crystalline solid |
| pka | 13.61±0.46(Predicted) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
ARV-771 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21299 | ARV-771 | 1949837-12-0 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 21299 | ARV-771 | 1949837-12-0 | 10mg | $253 | 2024-03-01 | Buy |
| Cayman Chemical | 21299 | ARV-771 | 1949837-12-0 | 5mg | $141 | 2024-03-01 | Buy |
| Tocris | 7256 | ARV771 ≥98%(HPLC) | 1949837-12-0 | 5 | $219 | 2021-12-16 | Buy |
| ChemScene | CS-6389 | ARV-771 99.82% | 1949837-12-0 | 1mg | $180 | 2021-12-16 | Buy |
ARV-771 Chemical Properties,Uses,Production
Description
ARV-771 is a BET PROTAC based on E3 ligase von Hippel-Lindau with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1) and BRD4(2), respectively.
Uses
ARV-771 is an effective BET degrader of the PROTAC class.
Biological Activity
ARV-771 is a potent pan-(bromodomain and extra-terminal) BET degrader, a novel BET-PROTAC (proteolysis-targeting chimera), for BRD2(1), BRD2(2), BRD3(1) The Kd values of , BRD3(2), BRD4(1) and BRD4(2) were 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM and 7.6 nM, respectively.
target
| Target | Value |
| BRD2-BD2 (Cell-free assay) | 4.7 nM(Kd) |
| BRD3-BD2 (Cell-free assay) | 7.6 nM(Kd) | td>
| BRD4-BD2 (Cell-free assay) | 7.6 nM(Kd) |
| BRD3-BD1 (Cell-free assay) | 8.3 nM(Kd) |
| BRD4-BD1 (Cell-free assay) | 9.6 nM(Kd) |
storage
Store at -20°C
ARV-771 Preparation Products And Raw materials
Raw materials
Preparation Products
ARV-771 Suppliers
Global( 88)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Chuchang Biotech Co., Ltd. | +86-18727130788 +86-18727130788 | info@chuchangbiotech.com | China | 100 | 58 |
| Shanghai finete Pharmaceutical Co., Ltd. | +86-18221039705 | CHINA | 139 | 55 | |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12770 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 6001 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
View Lastest Price from ARV-771 manufacturers
1949837-12-0(ARV-771)Related Search:
ARV-771
ARV 771; ARV771
(2S,4R)-1-[(2S)-2-[[2-[3-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
(2S,4R)-1-[(2S)-2-[[2-[3-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-
(2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
Epigenetic Reader Domain,ARV-771,ARV771,inhibit,ARV 771,PROTACs,Inhibitor
1949837-12-0
C49H60ClN9O7S2
ADC LINKER
API