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ChemicalBook >> CAS DataBase List >>2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Structure
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- structure
CAS No.
6318-41-8
Chemical Name:
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
Synonyms
PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem;2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-;5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione;Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K
CBNumber:
CB13232856
Molecular Formula:
C11H7NO4S
Molecular Weight:
249.24
MDL Number:
MFCD18382117
MOL File:
6318-41-8.mol
MSDS File:
SDS
Last updated:2023-07-09 08:28:05
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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Properties

Density 1.595±0.06 g/cm3(Predicted)
storage temp. +2C to +8C
solubility Soluble in DMSO (up to 25 mg/ml).
form Yellow solid
pka 7.13±0.20(Predicted)
color Yellow
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 528114 PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem 6318-41-8 5mg $238 2023-01-07 Buy
Alfa Aesar J67246 AS-041164 98% 6318-41-8 10mg $123 2021-12-16 Buy
Cayman Chemical 13622 AS-041164 6318-41-8 10mg $92 2024-03-01 Buy
Cayman Chemical 13622 AS-041164 6318-41-8 50mg $346 2024-03-01 Buy
Cayman Chemical 13622 AS-041164 6318-41-8 5mg $72 2024-03-01 Buy
Product number Packaging Price Buy
528114 5mg $238 Buy
J67246 10mg $123 Buy
13622 10mg $92 Buy
13622 50mg $346 Buy
13622 5mg $72 Buy

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Chemical Properties,Uses,Production

Description

The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC50 = 70 nM), compared to PI3Kα (IC50 = 240 nM), PI3Kβ (IC50 = 1.45 μM), and PI3Kδ (IC50 =1.70 μM). When tested at 1.0 μM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED50 = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.

References

1) Ferrandi et al. (2007) Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment: J. Pharmacol. Exp. Ther. 322 923

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- synthesis

2295-31-0
120-57-0
6318-41-8
Synthesis of 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- from 2,4-Thiazolidinedione and Piperonyl aldehyde

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Suppliers

Global( 22)Suppliers
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
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Supplier Advantage
TargetMol Chemicals Inc. 		58
InvivoChem 		58
Shanghai EFE Biological Technology Co., Ltd. 58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Shanghai Chaolan Chemical Technology Center 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
InvivoChem 58
TargetMol Chemicals Inc. 58

6318-41-8(2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-)Related Search:

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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K 5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione 6318-41-8