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ChemicalBook >> CAS DataBase List >>16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate

16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate

16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Structure
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate structure
CAS No.
77017-20-0
Chemical Name:
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
Synonyms
BNKY015-BD01;Desonide Impurity M1;Budesonide Impurity 33;Budesonide Impurity 12;Pregna-1,4,9(11)-triene-16,17-diol-3,20-dione 21-acetate;Pregna-1,4,9(11)-triene-16α,17α-diol-3,20-dione 21-acetate;16,17-Dihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate;21-(Acetyloxy)-16α,17-dihydroxypregna-1,4,9(11)-triene-3,20-dione;16α,17α,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione-21-acetate;(16α)-21-Acetyloxy-16,17-dihydroxy-pregna-1,4,9(11)-triene-3,20-dione
CBNumber:
CB1894903
Molecular Formula:
C23H28O6
Molecular Weight:
400.46482
MDL Number:
MFCD12031469
MOL File:
77017-20-0.mol
MSDS File:
SDS
Last updated:2024-03-15 11:58:08
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16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Properties

Melting point 213-215 °C(Solv: acetone (67-64-1); ligroine (8032-32-4))
Boiling point 576.7±50.0 °C(Predicted)
Density 1.31±0.1 g/cm3(Predicted)
solubility soluble in Acetone, Dichloromethane
pka 11.92±0.70(Predicted)
Water Solubility 38.72mg/L at 25℃
LogP 2.26 at 25℃
FDA UNII FWD7KH5JFZ

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS08,GHS07,GHS09
Signal word  Warning
Hazard statements  H335-H361-H315-H319-H411
Precautionary statements  P201-P202-P281-P308+P313-P405-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Medical Isotopes, Inc. 67632 (16α)-21-Acetyloxy-16,17-dihydroxy-pregna-1,4,9(11)-triene-3,20-dione 77017-20-0 10mg $640 2021-12-16 Buy
American Custom Chemicals Corporation CHM0006413 16,17,21-TRIHYDROXYPREGNA-1,4,9(11),TRIENE-3,20-DIONE-21-ACETATE 95.00% 77017-20-0 10MG $739.2 2021-12-16 Buy
American Custom Chemicals Corporation CHM0006413 16,17,21-TRIHYDROXYPREGNA-1,4,9(11),TRIENE-3,20-DIONE-21-ACETATE 95.00% 77017-20-0 100MG $1871.1 2021-12-16 Buy
Product number Packaging Price Buy
67632 10mg $640 Buy
CHM0006413 10MG $739.2 Buy
CHM0006413 100MG $1871.1 Buy

16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Chemical Properties,Uses,Production

Uses

Intermediate in the preparation of antiinflammatory compounds.

Synthesis

2-((10S,13S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate (1 kg, 2.73 mol), acetone (50 L) and purified water (2.6 L) were added to the reaction vessel, and dissolved by stirring at room temperature; Formic acid (0.4 L, 10.60 mol) and potassium permanganate (1.2 kg, 7.59 mol) were added in that order, and the reaction was stirred at room temperature for 1 h. The reaction was quenched by the addition of saturated sodium hydrogen sulfite solution (10 L) and manganese dioxide, and some solid impurities were removed by suction filtration, and the filtrate was evaporated under reduced pressure to give a large white solid. The filter cake was washed with water to give 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate (1.01 kg, 92.2%).
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate

16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate synthesis

37413-91-5
77017-20-0
Synthesis of 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate from 3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate

16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Preparation Products And Raw materials

Raw materials

3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate

Preparation Products

Prednisone Impurity 13

16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Suppliers

Global( 37)Suppliers
Supplier Tel Email Country ProdList Advantage
BIONNA MEDICINE CO.,LTD
01056380788-8515; +8618518759099 790226113@qq.com China 52 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
ZHEJIANG JIUZHOU CHEM CO., LTD 		+86-0576225566889 +86-13454675544 admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com China 19949 58
Wuhan Cell Pharmaceutical Co., Ltd 		+86-13129979210 +86-13129979210 sales@cellwh.com China 376 58
Hefei TianRui Pharmaceutical Chemical Co., Ltd. 		+86-0551-68665055 +86-+86-18616906106 sales@trywchem.com China 129 58
Bono Kangyuan (Beijing) Pharmaceutical Technology Co., Ltd 010-56380788-8515 16619769925 wch013@bionna.cn China 53 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32344 50
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-83725681-603 China 4505 50
Beijing Comparison Pharmaceutical Technology Co., Ltd 010-52878169 15701683040 sales@bjcomparison.com China 4713 58
Supplier Advantage
BIONNA MEDICINE CO.,LTD
58
Career Henan Chemica Co 		58
ZHEJIANG JIUZHOU CHEM CO., LTD 		58
Wuhan Cell Pharmaceutical Co., Ltd 		58
Hefei TianRui Pharmaceutical Chemical Co., Ltd. 		58
Bono Kangyuan (Beijing) Pharmaceutical Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Chemsky（shanghai）International Co.,Ltd. 50
S.Z. PhyStandard Bio-Tech. Co., Ltd. 50
Beijing Comparison Pharmaceutical Technology Co., Ltd 58

77017-20-0(16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate)Related Search:

Budesonide Impurity 30 Prednisone 17, 21-Diacetate 11beta,16alpha,17,21-tetrahydroxypregn-4-ene-3,20-dione Budesonide Impurity 11 Budesonide Impurity 7
21-Dehydro Budesonide 16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers) (11β,16α)-21-(Acetyloxy)-11,16,17-trihydroxypregna-1,4,14-triene-3,20-dione 11beta,21-dihydroxypregna-1,4,16-triene-3,20-dione 21-acetate GOJZZYSAJXCRGI-KXGXINSVSA-N
16α,17,21-Trihydroxy-pregna-1,4-diene-3,11,20-trione Budesonide iMpurity Budesonide Impurity (1, 4-Androstadien-11-beta-16-alfa-diol-3, 17-dione) Budesonide Impurity 6 21-Dehydro-16α-hydroxy Prednisolone
2,4,6-tripropyl-1,3,5-trioxane Budesonide (r)-budesonide

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16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate 16,17-Dihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate 16-alpha,17-alpha-dihydroxy-3,20-dioxopregna- 1,4,9(11)-trien-21-yl acetate Pregna-1,4,9(11)-triene-16,17-diol-3,20-dione 21-acetate 21-(Acetyloxy)-16α,17-dihydroxypregna-1,4,9(11)-triene-3,20-dione (16α)-21-Acetyloxy-16,17-dihydroxy-pregna-1,4,9(11)-triene-3,20-dione BNKY015-BD01 Budesonide Impurity 12 Pregna-1,4,9(11)-triene-3,20-dione, 21-(acetyloxy)-16,17-dihydroxy-, (16α)- Pregna-1,4,9(11)-triene-3,20-dione,21-(acetyloxy)-16,17-dihydroxy-, (16a)- (9CI) Budesonide Impurity 33 16α,17α,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione-21-acetate Desonide Impurity M1 "(16a)-21-Acetyloxy-16,17-dihydroxy-pregna-1,4,9(11)-triene-3,20-dione" 2-((8S,10S,13S,14S,16R,17S)-16,17-Dihydroxy-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate Pregna-1,4,9(11)-triene-16α,17α-diol-3,20-dione 21-acetate 2-[(8S,10S,13S,14S,16R,17S)-16,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]acetate 77017-20-0 Intermediates & Fine Chemicals Pharmaceuticals Steroids