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3-Oxobetulin Acetate

3-Oxobetulin Acetate Structure
3-Oxobetulin Acetate structure
CAS No.
136587-07-0
Chemical Name:
3-Oxobetulin Acetate
Synonyms
3-Oxobetulin Acetate;28-(acetyloxy)-lup-20(29)-en-3-one;Lup-20(29)-en-3-one, 28-(acetyloxy)-
CBNumber:
CB19739340
Molecular Formula:
C32H50O3
Molecular Weight:
482.74
MDL Number:
MFCD32692729
MOL File:
136587-07-0.mol
Last updated:2023-05-21 10:59:17
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3-Oxobetulin Acetate Properties

Melting point 77-79 °C
Boiling point 532.7±23.0 °C(Predicted)
Density 1.019±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 25 mg/ml
form A crystalline solid

3-Oxobetulin Acetate Chemical Properties,Uses,Production

Biological Activity

3-Oxobetulin acetate is a derivative of the cholesterol biosynthesis inhibitor betulin .1 It inhibits the growth of P388 murine lymphocytic leukemia cells (EC50 = 0.12 μg/ml), as well as human MCF-7 breast, SF-268 CNS, H460 lung, and KM20L2 colon cancer cells (GI50s = 8, 10.6, 5.2, and 12.7 μg/ml, respectively), but not BxPC-3 pancreas or DU145 prostate cancer cells (GI50s = >10 μg/ml for both).2 3-Oxobetulin acetate inhibits replication of X4 tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblastoid cells (IC50 = 13.4 μM).3 It is also active against L. donovani amastigotes when used at a concentration of 50 μM.1

References

1.Alakurtti, S., Bergstr?m, P., Sacerdoti-Sierra, N., et al.Anti-leishmanial activity of betulin derivativesJ. Antibiot. (Tokyo)63(3)123-126(2010) 2.Pettit, G.R., Melody, N., Hempenstall, F., et al.Antineoplastic agents. 595. Structural modifications of betulin and the X-ray crystal structure of an unusual betulin amine dimerJ. Nat. Prod.77(4)863-872(2014) 3.Callies, O., Bedoya, L.M., Beltrán, M., et al.Isolation, structural modification, and HIV inhibition of pentacyclic lupane-type triterpenoids from Cassine xylocarpa and Maytenus cuzcoinaJ. Nat. Prod.78(5)1045-1055(2015)

3-Oxobetulin Acetate Preparation Products And Raw materials

Raw materials

Preparation Products

3-Oxobetulin Acetate Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
ChemeGen 中国 18818260767 sales@chemegen.com China 6975 58
Beijing Biocreative Technology Co., Ltd. 15522676233 3007606172@qq.com China 1249 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.com China 24246 58
Supplier Advantage
ChemeGen 中国 58
Beijing Biocreative Technology Co., Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
3-Oxobetulin Acetate Lup-20(29)-en-3-one, 28-(acetyloxy)- 28-(acetyloxy)-lup-20(29)-en-3-one 136587-07-0