Chlorthalidone Impurity G
- CAS No.
- 16289-13-7
- Chemical Name:
- Chlorthalidone Impurity G
- Synonyms
- Chloro Chlorthalidone;Chlorthalidone Impurity G;Chlorthalidone EP Impurity G;Chlortalidone EP Impurity G;Chlortalidone (Chlorthalidone) EP Impurity G;3-(3,4-Dichlorophenyl)-3-hydroxy-phthalimidin;(3-(3,4-Dichlorophenyl)-3-hydroxy-phthalimidine);3-(3,4-Dichlorophenyl)-3-hydroxyisoindolin-1-one;3-(3,4-dichlorophenyl)-3-hydroxy-2H-isoindol-1-one;Chlortalidone Impurity 7（Chlortalidone EP Impurity G）
- CBNumber:
- CB21176203
- Molecular Formula:
- C14H9Cl2NO2
- Molecular Weight:
- 294.13
- MDL Number:
- MFCD18252405
- MOL File:
- 16289-13-7.mol
| Melting point | 197-2010C |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White |
| CAS DataBase Reference | 16289-13-7 |
| FDA UNII | EYL26UC6Q7 |
Chlorthalidone Impurity G price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22574 | Chlorthalidone Impurity G ≥98% | 16289-13-7 | 1mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 22574 | Chlorthalidone Impurity G ≥98% | 16289-13-7 | 500μg | $51 | 2023-01-06 | Buy |
| Cayman Chemical | 22574 | Chlorthalidone Impurity G ≥98% | 16289-13-7 | 5mg | $146 | 2024-03-01 | Buy |
| TRC | C427520 | ChloroChlorthalidone | 16289-13-7 | 10mg | $180 | 2021-12-16 | Buy |
| Biosynth Carbosynth | IC20415 | Chlorthalidone impurity G | 16289-13-7 | 2mg | $200 | 2021-12-16 | Buy |
Chlorthalidone Impurity G Chemical Properties,Uses,Production
Description
Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) and, to a lesser extent, CAI, CAII, IV, VA, and VI (Kis = 138-1,347 nM), which may mediate its sustained vasodilatory activity. Dietary administration of chlorthalidone (8 mg per animal per day) reduces arterial hypertension and prevents or reduces ventricular hypertrophy in DOCA-salt hypertensive rats. Formulations containing chlorthalidone have been used alone or in combination with other antihypertensive agents to lower arterial blood pressure and as adjuvants to address edema caused by cardiac or renal disorders.
Chemical Properties
White Solid
Uses
Chlorthalidone impurity. Antihypertensive agent.
Chlorthalidone Impurity G Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Guangzhou PI PI Biotech Inc | +86-020-81716320 +86-13602409664 | Sales@pipitech.com | China | 3635 | 55 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 17993 | 56 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9507 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |