morpholin-3-one
- CAS No.
- 109-11-5
- Chemical Name:
- morpholin-3-one
- Synonyms
- 3-MORPHOLINONE;3-Oxomorpholine;in-3-on;3-morpholone;JACS-109-11-5;Morpholin-3-on;MORPHOLIN-3-ONE;morpholine-3-one;3-Ketomorpholine;3-Morpholinone>
- CBNumber:
- CB2121662
- Molecular Formula:
- C4H7NO2
- Molecular Weight:
- 101.1
- MDL Number:
- MFCD00631009
- MOL File:
- 109-11-5.mol
- MSDS File:
- SDS
| Melting point | 103.0 to 107.0 °C |
|---|---|
| Boiling point | 142°C/7mmHg(lit.) |
| Density | 1.122±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 14.37±0.20(Predicted) |
| color | White to Almost white |
| CAS DataBase Reference | 109-11-5(CAS DataBase Reference) |
| FDA UNII | V6P29M33NG |
| EPA Substance Registry System | 3-Morpholinone (109-11-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302+H312+H332-H315-H317-H318 |
| Precautionary statements | P280 |
| Safety Statements | 24/25 |
| HS Code | 29349990 |
morpholin-3-one price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2788 | 3-Morpholinone >98.0%(GC) | 109-11-5 | 5g | $56 | 2024-03-01 | Buy |
| TCI Chemical | M2788 | 3-Morpholinone >98.0%(GC) | 109-11-5 | 25g | $198 | 2024-03-01 | Buy |
| TRC | M723840 | 3-Morpholinone | 109-11-5 | 10g | $75 | 2021-12-16 | Buy |
| TRC | M723840 | 3-Morpholinone | 109-11-5 | 1g | $45 | 2021-12-16 | Buy |
| Matrix Scientific | 074514 | Morpholin-3-one 95+% | 109-11-5 | 25g | $48 | 2021-12-16 | Buy |
morpholin-3-one Chemical Properties,Uses,Production
Description
3-ketomorpholine is also known as morpholin-3-one. It is useful pharmacological intermediate. Recent studies have shown that some morpholin-3-one derivatives could effectively cause cell cycle arrest at G1 phase, increase the levels of P53 and Fas, and induce A549 cell apoptosis in lung cancer. This indicates it might be a useful tool for elucidating the molecular mechanism of lung cancer cell apoptosis and might also be potential anti-cancer drugs. Some of its derivatives have been proven to be useful for the prevention and treatment of arteriosclerosis and hypertriglyceridemia.
Uses
3-Morpholinone is used as a reactant in the synthesis of 3-Morpholinone derivates. An example of this is 4-(4-Aminophenyl)-3-morpholinone, the key intermediate in the synthesis of Rivaroxaban (an anticoagulant).
References
He, Q., et al. "Novel morpholin-3-one derivatives induced apoptosis and elevated the level of P53 and Fas in A549 lung cancer cells." Bioorganic & Medicinal Chemistry 15.11(2007): 3889.
Murai, Hiromu, et al. "Morpholinone derivatives and method of use." US, US4237132. 1980.
Gonzalez-garcia, Maria Rosario, and Fernandez, Maria Carmen. "Morpholinyl derivatives useful as MOGAT-2 inhibitors." (2015).
morpholin-3-one Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
View Lastest Price from morpholin-3-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-13 | morpholin-3-one
109-11-5
|
US $40.00-36.00 / kg | 1kg | 99.99% | 100Tons | Hebei Dangtong Import and export Co LTD | |
 |
2024-01-08 | 3-Morpholinone
109-11-5
|
US $9.00 / KG | 1KG | 99% | 50000tons | Wuhan Boyuan Import & Export Co., LTD | |
 |
2023-08-16 | 3-Morpholinone
109-11-5
|
US $145.00 / KG | 1KG | >99% | 50000kg/Month | Weijer International Trade (Hebei) Co., Ltd |
-
- morpholin-3-one
109-11-5
- US $40.00-36.00 / kg
- 99.99%
- Hebei Dangtong Import and export Co LTD
-
- 3-Morpholinone
109-11-5
- US $9.00 / KG
- 99%
- Wuhan Boyuan Import & Export Co., LTD
-
- 3-Morpholinone
109-11-5
- US $145.00 / KG
- >99%
- Weijer International Trade (Hebei) Co., Ltd
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