kukoamine A
- CAS No.
- 75288-96-9
- Chemical Name:
- kukoamine A
- Synonyms
- NSC5398;NSC 5398;NSC-5398;kukoamine A;1,14-Bis(dihydrocaffeoyl)spermidine;N1,N12-Bis(dihydrocaffeoyl) spermine;N,N'-[Tetramethylenebis(iminotrimethylene)]bis[3-(3,4-dihydroxyphenyl)propionamide];N,N'-[1,4-Butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxybenzenepropanamide];Benzenepropanamide,N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy-;N,N'-((butane-1,4-diylbis(azanediyl))bis(propane-3,1-diyl))bis(3-(3,4-dihydroxyphenyl)propanamide)
- CBNumber:
- CB21355400
- Molecular Formula:
- C28H42N4O6
- Molecular Weight:
- 530.66
- MDL Number:
- MFCD29904538
- MOL File:
- 75288-96-9.mol
| Boiling point | 872.1±65.0 °C(Predicted) |
|---|---|
| Density | 1.213±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml |
| form | A crystalline solid |
| pka | 9.48±0.10(Predicted) |
| CAS DataBase Reference | 75288-96-9 |
| FDA UNII | 9YM64FBW2R |
kukoamine A price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL83866 | Kukoamine A phyproof? Reference Substance | 75288-96-9 | 10MG | $688 | 2024-03-01 | Buy |
| Cayman Chemical | 25139 | Kukoamine A ≥95% | 75288-96-9 | 1mg | $38 | 2024-03-01 | Buy |
| Cayman Chemical | 25139 | Kukoamine A ≥95% | 75288-96-9 | 5mg | $176 | 2024-03-01 | Buy |
| Cayman Chemical | 25139 | Kukoamine A ≥95% | 75288-96-9 | 10mg | $330 | 2024-03-01 | Buy |
| Usbiological | 300534 | Kukoamine A | 75288-96-9 | 10mg | $618 | 2021-12-16 | Buy |
kukoamine A Chemical Properties,Uses,Production
Description
Kukoamine A is a spermine alkaloid originally isolated from L. chinense that has diverse biological activities, including anticancer, neuroprotective, and anti-inflammatory properties. Kukoamine A (5-20 μg/ml) inhibits colony formation of U251 and WJ1 glioblastoma cells in a concentration-dependent manner. It halts the cell cycle at the G0/G1 phase and induces apoptosis when used at concentrations of 60 and 80 μg/ml. Kukoamine A (20 and 40 μM) induces autophagy and increases cell viability in an SH-SY5Y cell model of MPP-induced injury. It increases the number of dopamine neurons in the substantia nigra and striatum, decreases α-synuclein expression, and improves motor function in an MPTP mouse model of Parkinson’s disease when administered at a dose of 20 mg/kg per day. Kukoamine A (10 and 20 mg/kg) decreases IL-1β, TNF-α, and COX-2 protein levels in the hippocampus and increases hippocampal neurogenesis in a rat model of radiation injury. It also selectively inhibits trypanothione reductase (Ki = 1.8 μM), an enzyme that protects certain parasites from oxidative stress, over human glutathione reductase (Ki = >10 mM).
Occurrence
The root bark of Lychium chinense yields this alkaloid. Kukoamine A possesses hypotensive activity inducing hypotension in rats at a dose of 5 mg/kg when given intravenously.
Uses
Kukoamine A is a neuroprotective agent which is used to prevent the loss of dopaminergic neurons in substantia nigra.
Definition
ChEBI: Kukoamine A is an amine.
kukoamine A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | +8618283602253 | jancyzheng@gcgreenpure.com | China | 952 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from kukoamine A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-21 | kukoamine A
75288-96-9
|
US $8.00 / KG | 1g | ＞98% HPLC | kg--ton | Career Henan Chemical Co |
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- kukoamine A
75288-96-9
- US $8.00 / KG
- ＞98% HPLC
- Career Henan Chemical Co