2-Fluoro-4-hydroxybenzaldehyde
- CAS No.
- 348-27-6
- Chemical Name:
- 2-Fluoro-4-hydroxybenzaldehyde
- Synonyms
- 3-Fluoro-4-formylphenol;2-Fluoro-6-nitroacetophenone;2-FLURO-4-HYDROXYBENZALDEHYDE;2-FLUORO-4-HYDROXYBENZALDEHYDE;Benzaldehyde, 2-fluoro-4-hydroxy-;2-Fluoro-4-hydroxybenzaldehyde,98%
- CBNumber:
- CB2214861
- Molecular Formula:
- C7H5FO2
- Molecular Weight:
- 140.11
- MDL Number:
- MFCD06797918
- MOL File:
- 348-27-6.mol
| Melting point | 168-170°C |
|---|---|
| Boiling point | 254.2±20.0 °C(Predicted) |
| Density | 1.350±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | crystalline powder |
| pka | 6.78±0.18(Predicted) |
| color | Light tan |
| InChI | InChI=1S/C7H5FO2/c8-7-3-6(10)2-1-5(7)4-9/h1-4,10H |
| InChIKey | ONRPXRPUBXXCCM-UHFFFAOYSA-N |
| SMILES | C(=O)C1=CC=C(O)C=C1F |
| CAS DataBase Reference | 348-27-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-37/38-41-52 | |||||||||
| Safety Statements | 26-39 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2912490090 | |||||||||
| NFPA 704 |
|
2-Fluoro-4-hydroxybenzaldehyde price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | H26218 | 2-Fluoro-4-hydroxybenzaldehyde, 97% | 348-27-6 | 100mg | $99.65 | 2024-03-01 | Buy |
| Alfa Aesar | H26218 | 2-Fluoro-4-hydroxybenzaldehyde, 97% | 348-27-6 | 500mg | $292.65 | 2024-03-01 | Buy |
| TRC | F597973 | 2-Fluoro-4-hydroxybenzaldehyde | 348-27-6 | 100mg | $45 | 2021-12-16 | Buy |
| Matrix Scientific | 072823 | 2-Fluoro-4-hydroxybenzaldehyde 95+% | 348-27-6 | 5g | $69 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0019786 | 2-FLUORO-4-HYDROXYBENZALDEHYDE 95.00% | 348-27-6 | 250MG | $126 | 2021-12-16 | Buy |
2-Fluoro-4-hydroxybenzaldehyde Chemical Properties,Uses,Production
Uses
2-Fluoro-4-hydroxybenzaldehyde is a useful reagent for preparation of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors.
Uses
2-Fluoro-4-hydroxybenzaldehyde is mainly used as an intermediate for physiologically active compounds such as pharmaceuticals or pesticides and is a wide range of organic building blocks. Its structure contains fluorine, aldehyde groups, and phenolic hydroxyl groups, and these groups can add or replace other functional groups.
Synthesis
Preparation of 2-fluoro-4-hydroxybenzaldehyde involves: (1) mixing 3-fluorophenol (I), potassium carbonate, and 2-bromopropane in an organic solvent, and heating to react to obtain 1-fluoro-3-isopropoxybenzene (II); (2) dissolving compound (II) in an organic solvent and reacting with a brominating reagent to obtain 1-bromo-2-fluoro-4-isopropoxybenzene (III); (3) dissolving compound (III) in tetrahydrofuran, dripping isopropylmagnesium chloride/tetrahydrofuran solution at -10°C to 0°C, adding dimethylformamide to react after Grignard exchange to obtain 2-fluoro-4-isopropoxybenzaldehyde (IV); and (4) reacting compound (IV) with boron trichloride and deprotecting.
2-Fluoro-4-hydroxybenzaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12471 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 18232 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753; +8613336034509 | sales@fluoropharm.com | China | 1377 | 60 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4242 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
View Lastest Price from 2-Fluoro-4-hydroxybenzaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-08 | 2-Fluoro-4-hydroxybenzaldehyde
348-27-6
|
US $34.00-1.20 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-07-28 | 2-Fluoro-4-hydroxybenzaldehyde
348-27-6
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-02-14 | 2-Fluoro-4-hydroxybenzaldehyde
348-27-6
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Guanlang Biotechnology Co., Ltd. |
-
- 2-Fluoro-4-hydroxybenzaldehyde
348-27-6
- US $34.00-1.20 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Fluoro-4-hydroxybenzaldehyde
348-27-6
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- 2-Fluoro-4-hydroxybenzaldehyde
348-27-6
- US $0.00-0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
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