TRANYLCYPROMINE
- CAS No.
- 95-62-5
- Chemical Name:
- TRANYLCYPROMINE
- Synonyms
- AURORA KA-7804;TRANS-LAMINO-2-PHENYLCYCLOPROPANE;TRANS-1-AMINO-2-PHENYLCYCLOPROPANE;[(1R,2S)-2-phenylcyclopropyl]amine;(1R,2S)-2-phenylcyclopropan-1-amine;Cyclopropanamine, 2-phenyl-, trans-;(1R,2S)-1-amino-2-phenylcyclopropane;rel-2β*-Phenylcyclopropane-1α*-amine;TRANS-2-PHENYLCYCLOPROPYLAMINE HYDROCHLO RIDE (TRANYLCYPROMINE HCL);(-)-Tranylcypromine D5 HydrochlorideQ: What is (-)-Tranylcypromine D5 Hydrochloride Q: What is the CAS Number of (-)-Tranylcypromine D5 Hydrochloride Q: What is the storage condition of (-)-Tranylcypromine D5 Hydrochloride Q: What are the applications of (-)-Tranylcypromine D5 Hydrochloride
- CBNumber:
- CB2229157
- Molecular Formula:
- C9H11N
- Molecular Weight:
- 133.19
- MDL Number:
- MFCD00001302
- MOL File:
- 95-62-5.mol
| pka | pKa 8.2 (Uncertain) |
|---|---|
| FDA UNII | 3E3V44J4Z9 |
TRANYLCYPROMINE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | CCH0007635 | (1R,2S)-2-PHENYLCYCLOPROPAN-1-AMINE 95.00% | 95-62-5 | 5MG | $500.65 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0007635 | (1R,2S)-2-PHENYLCYCLOPROPAN-1-AMINE 95.00% | 95-62-5 | 1G | $1260 | 2021-12-16 | Buy |
TRANYLCYPROMINE Chemical Properties,Uses,Production
Definition
ChEBI: (1R,2S)-tranylcypromine is a 2-phenylcyclopropan-1-amine that is the (1R,2S)-enantiomer of tranylcypromine. It is a conjugate base of a (1R,2S)-tranylcypromine(1+). It is an enantiomer of a (1S,2R)-tranylcypromine.
Clinical Use
Tranylcypromine is a nonhydrazine, irreversible MAO inhibitor antidepressant agent that was designed as the cyclopropyl analogue of amphetamine. Instead of exhibiting amphetamine-like stimulation, its mechanism of action is nonselective, irreversible inhibition of MAO. Its onset of antidepressant action is more rapid than for phenelzine. Tranylcypromine is well absorbed following oral administration. Metabolism occurs via aromatic ring hydroxylation and N-acetylation. It is a competitive inhibitor of CYP2C19 and CYP2D6 and a noncompetitive inhibitor of CYP 2C9. Most metabolism studies suggest that tranylcypromine is not metabolized to amphetamine contrary to debate. Maximal MAO inhibition, however, occurs within 5 to 10 days. The GI absorption of the tranylcypromine shows interindividual variation and may be biphasic in some individuals, achieving an initial peak within approximately 1 hour and a secondary peak within 2 to 3 hours. It has been suggested that this apparent biphasic absorption in some individuals may represent different absorption rates. Following discontinuance of tranylcypromine, the drug is excreted within 24 hours. On withdrawal of tranylcypromine, MAO activity is recovered in 3 to 5 days (possibly in up to 10 days). Concentrations of urinary tryptamine, an indicator of MAO-A inhibition return to normal, however, within 72 to 120 hours.
TRANYLCYPROMINE Preparation Products And Raw materials
Raw materials
Preparation Products
TRANYLCYPROMINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Sunway Pharmaceutical Technology Co.,Ltd. | 021-51816796-820 13611835272 | sales2@sunwaypharm.com | China | 44489 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 029-81124267 15229202216 | 1073@dideu.com | China | 10011 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Sunway Pharmaceutical Technology Co.,Ltd. | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 58 |