(±)11(12)-EET
- CAS No.
- 123931-40-8
- Chemical Name:
- (±)11(12)-EET
- Synonyms
- 11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid ~100 mug/mL in ethanol, >=95%;5,8-Decadienoic acid, 10-[(2S,3R)-3-(2Z)-2-octen-1-yl-2-oxiranyl]-, (5Z,8Z)-
- CBNumber:
- CB22589778
- Molecular Formula:
- C20H32O3
- Molecular Weight:
- 320.47
- MDL Number:
- MFCD00132914
- MOL File:
- 123931-40-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P305+P351+P338 | |||||||||
| Hazard Codes | F | |||||||||
| Risk Statements | 11 | |||||||||
| Safety Statements | 7-16 | |||||||||
| RIDADR | UN1170 - class 3 - PG 2 - Ethanol, solution | |||||||||
| WGK Germany | 1 | |||||||||
| NFPA 704 |
|
(±)11(12)-EET price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E5641 | 11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid ~100?μg/mLinethanol,≥95% | 123931-40-8 | 25μg | $294 | 2024-03-01 | Buy |
| Cayman Chemical | 50511 | (±)11(12)-EET ≥95% | 123931-40-8 | 25μg | $44 | 2023-06-20 | Buy |
| Cayman Chemical | 50511 | (±)11(12)-EET ≥95% | 123931-40-8 | 50μg | $79 | 2023-06-20 | Buy |
| Cayman Chemical | 50511 | (±)11(12)-EET ≥95% | 123931-40-8 | 100μg | $138 | 2023-06-20 | Buy |
| Cayman Chemical | 50511 | (±)11(12)-EET ≥95% | 123931-40-8 | 500μg | $428 | 2023-06-20 | Buy |
(±)11(12)-EET Chemical Properties,Uses,Production
Description
(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET. 11(12)-EET has been shown, along with 8(9)-EET , to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells. It also inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct when used at a concentration of 100 nM. 11(12)-EET (50 μg/kg per day) increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 but does not affect choroidal neovascularization size following laser photocoagulation. It also has anti-inflammatory, angiogenic, and cardioprotective properties.
Uses
14(15)-Epoxy-5Z,8Z,11Z-eicosatrienoic Acid-D11 is a deuterium labelled 14(15)-Epoxy-5Z,8Z,11Z-eicosatrienoic Acid (E350670), which is a useful research chemical that acts as an endothelium-derived hyperpolarizing factor in bovine coronary arteries to mediate vascular effects of vasoactive hormones.
(±)11(12)-EET Preparation Products And Raw materials
Raw materials
Preparation Products
(±)11(12)-EET Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 18521735133 18521732826; | market@aladdin-e.com | China | 25014 | 65 |
| Yichang Zhongyitai Trading Co., Ltd. | 0717-6449896 13886658719 | root@zhongyitai.com | China | 1977 | 58 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9171 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |