4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine
- CAS No.
- 1357476-67-5
- Chemical Name:
- 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine
- Synonyms
- 100346;4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl);4-Bromo-2-(2,2,2-trifluoro-1,1-dimethylethyl)pyridine;4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine;Pyridine, 4-bromo-2-(2,2,2-trifluoro-1,1-dimethylethyl)-
- CBNumber:
- CB22598749
- Molecular Formula:
- C9H9BrF3N
- Molecular Weight:
- 268.07
- MDL Number:
- MFCD22393679
- MOL File:
- 1357476-67-5.mol
- MSDS File:
- SDS
| Boiling point | 209.3±40.0 °C(Predicted) |
|---|---|
| Density | 1.473±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 2.29±0.10(Predicted) |
| InChI | InChI=1S/C9H9BrF3N/c1-8(2,9(11,12)13)7-5-6(10)3-4-14-7/h3-5H,1-2H3 |
| InChIKey | XAQNICQGPIHIIH-UHFFFAOYSA-N |
| SMILES | C1(C(C)(C)C(F)(F)F)=NC=CC(Br)=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B421233 | 4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine | 1357476-67-5 | 10mg | $65 | 2021-12-16 | Buy |
| TRC | B421233 | 4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine | 1357476-67-5 | 50mg | $220 | 2021-12-16 | Buy |
| Matrix Scientific | 120592 | 4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine 97% | 1357476-67-5 | 250mg | $1072 | 2021-12-16 | Buy |
| Matrix Scientific | 120592 | 4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine 97% | 1357476-67-5 | 1g | $3232 | 2021-12-16 | Buy |
| Chemenu | CM173026 | 4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine 95% | 1357476-67-5 | 1g | $716 | 2021-12-16 | Buy |
4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine Chemical Properties,Uses,Production
Synthesis
To a solution of 18-6 (8.7 g, 42.40 mmol, 1 eq) in 1,2-dichloroethane (90 mL) was added Phosphorus(V) oxybromide (18.23 g, 63.60 mmol, 6.47 mL, 1.5 eq). The mixture was stirred at 80°C for 4 hours. TLC (Petroleum ether: Ethyl acetate: Ethanol =4:3:1) showed a part of starting material was remained. Another Phosphorus (V) oxybromide (6.08 g, 21.20 mmol, 2.16 mL, 0.5 eq) was added into the mixture. The reaction mixture was stirred at 80°C for another 3 hours. TLC (Petroleum ether: ethyl acetate: ethanol=4:3:1) showed the starting material was consumed completely. The mixture was combined with another batch (1 g scale) and then poured into ice saturated sodium bicarbonate solution (300 mL) and adjust the pH=7~8. The mixture was extracted with ethyl acetate (100 mLx3). The combined organic layers were washed with brine (100 mL), dried over anhydrous sodium sulfate, filtered, concentrated in vacuum. The residue was purified by column chromatography (SiO2, Petroleum ether: ethyl acetate=1:0 to 50:11) to give 18-7 (8.5 g, 31.71 mmol, 67.37% yield, 100% purity) as light yellow oil.
Synthesis
4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Unibest Industrial Co.,Ltd. | +86-8657427855777 +86-18758850676 | info@unibestcn.com | China | 350 | 58 |
| Chengdu Feibo Pharm Technology Co., Ltd | 15982321820 | abby@arkpharm.com | CHINA | 3279 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Xi'an Yutbon Pharmaceutical Technology Co., Ltd | 029-81140587 +8618717328141 | sales@yutbon.com | China | 453 | 58 |
| CR Corporation Lomited | fred.wen@crcorporation.cn | CHINA | 12069 | 58 | |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 | guoyuan@eastchinapharm.com | China | 1615 | 58 |
| Golden Pharma Co., Limited | +undefined18958062155 | sales@zjgoldpharm.com | China | 5905 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9425 | 58 |
View Lastest Price from 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2022-09-28 | 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine
1357476-67-5
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine
1357476-67-5
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.