Nepicastat hydrochloride
- CAS No.
- 170151-24-3
- Chemical Name:
- Nepicastat hydrochloride
- Synonyms
- SYN-117 HCl;Nepicastat HCl, >=99%;SYN-117 hydrochloride;Nepicastat (SYN117)HCI;Nepicastat HCl (SYN-117);NEPICASTAT HYDROCHLORIDE;Nepicastat (SYN-117) HCl;RS-25560-197 hydrochloride);Nepicastat (SYN-117) hydrochloride;Nepicastat hydrochloride USP/EP/BP
- CBNumber:
- CB22611129
- Molecular Formula:
- C14H16ClF2N3S
- Molecular Weight:
- 331.81
- MDL Number:
- MFCD00954638
- MOL File:
- 170151-24-3.mol
- MSDS File:
- SDS
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| color | white to beige |
| InChIKey | DIPDUAJWNBEVOY-PPHPATTJSA-N |
| FDA UNII | 3WK068D17I |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
Nepicastat hydrochloride price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0940 | Nepicastat hydrochloride ≥95% (HPLC) | 170151-24-3 | 5mg | $115 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0940 | Nepicastat hydrochloride ≥95% (HPLC) | 170151-24-3 | 25mg | $462 | 2024-03-01 | Buy |
| Cayman Chemical | 22126 | Nepicastat (hydrochloride) | 170151-24-3 | 1mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 22126 | Nepicastat (hydrochloride) | 170151-24-3 | 5mg | $96 | 2024-03-01 | Buy |
| Cayman Chemical | 22126 | Nepicastat (hydrochloride) | 170151-24-3 | 10mg | $176 | 2024-03-01 | Buy |
Nepicastat hydrochloride Chemical Properties,Uses,Production
Description
Nepicastat is an inhibitor of dopamine β-hydroxylase (DBH; IC50 = 9 nM for the purified human enzyme). It is selective for DBH over a panel of 12 enzymes and 13 neurotransmitter receptors (IC50s or Kis = >10 μM). Nepicastat dose-dependently reduces norepinephrine content and increases dopamine content in the mesenteric artery, left ventricle, and cerebral cortex in spontaneously hypertensive rats, as well as in the renal artery, left ventricle, and cerebral cortex in beagle dogs. It attenuates increases in diastolic blood pressure and heart rate induced by preganglionic sympathetic nerve stimulation in pithed spontaneously hypertensive rats when administered orally at doses of 10 and 30 mg/kg. Nepicatstat (50 mg/kg) reduces the progressive ratio response for cocaine, but not food or sucrose pellets, in rats. It also reduces reinstatement of cocaine-seeking behavior induced by cues, yohimbine , or foot-shock in rats.
Uses
Nepicastat Hydrochloride is a potent and selective dopamine β-hydrolase inhibitor. Used in cardiovascular treatment where deficiencies in ventricles results in heart failure.
storage
Store at -20°C
References
[1]. stanley wc, li b, bonhaus dw, et al. catecholamine modulatory effects of nepicastat (rs-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. br j pharmacol, 1997, 121(8): 1803-1809.
[2]. stanley wc, lee k, johnson lg, et al. cardiovascular effects of nepicastat (rs-25560-197), a novel dopamine beta-hydroxylase inhibitor. j cardiovasc pharmacol, 1998, 31(6): 963-970.
[3]. devoto p, flore g, saba p, et al. the dopamine beta-hydroxylase inhibitor nepicastat increases dopamine release and potentiates psychostimulant-induced dopamine release in the prefrontal cortex. addict biol, 2014, 19(4): 612-622.
Nepicastat hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Wuhan Monad Medicine Tech Co.,LTD | 02768782018 18771942761 | sales01@whmonad.com | CHINA | 992 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Apeloa Pharmaceutical Co., Ltd. | +86-0571-87635730 +8615858229168 | chem1022@hengdian-group.com | China | 1478 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27644 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
View Lastest Price from Nepicastat hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-31 | Nepicastat HCl
170151-24-3
|
US $50.00 / KG | 1Kg/Bag | 99.99% | 20 tons/month | Wuhan Monad Medicine Tech Co.,LTD | |
 |
2020-01-09 | Nepicastat hydrochloride
70151-24-3
|
US $2.00 / KG | 1g | 98%min | ask | Career Henan Chemical Co |
-
- Nepicastat HCl
170151-24-3
- US $50.00 / KG
- 99.99%
- Wuhan Monad Medicine Tech Co.,LTD
-
- Nepicastat hydrochloride
70151-24-3
- US $2.00 / KG
- 98%min
- Career Henan Chemical Co