Tarafenacin
- CAS No.
- 385367-47-5
- Chemical Name:
- Tarafenacin
- Synonyms
- CS-929;SVT407776;Tarafenacin;Tarafenacin, >=98%;Tarafenacin(SVT-40776);SVT-40776 (Tarafenacin);SVT-40776; SVT40776; SVT 40776;[(3R)-1-azabicyclo[2.2.2]octan-3-yl] N-(3-fluorophenyl)-N-[(3,4,5-trifluorophenyl)methyl]carbamate;N-(3-Fluorophenyl)-N-[(3,4,5-trifluorophenyl)methyl]carbamic acid (3R)-1-azabicyclo[2.2.2]oct-3-yl ester;Carbamic acid, N-(3-fluorophenyl)-N-[(3,4,5-trifluorophenyl)methyl]-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester
- CBNumber:
- CB22628444
- Molecular Formula:
- C21H20F4N2O2
- Molecular Weight:
- 408.3893128
- MDL Number:
- MFCD19443715
- MOL File:
- 385367-47-5.mol
| Boiling point | 483.4±45.0 °C(Predicted) |
|---|---|
| Density | 1.38 |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 8.80±0.33(Predicted) |
| FDA UNII | LDV98UN52Y |
Tarafenacin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | B1132 | Tarafenacin | 385367-47-5 | 10mg | $501 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0013711 | TARAFENACIN 95.00% | 385367-47-5 | 10MG | $618.45 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180991 | Tarafenacin(SVT-40776) >98% | 385367-47-5 | 100mg | $1208.7 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0013711 | TARAFENACIN 95.00% | 385367-47-5 | 100MG | $2310 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180991 | Tarafenacin(SVT-40776) >98% | 385367-47-5 | 250mg | $2395.3 | 2021-12-16 | Buy |
Tarafenacin Chemical Properties,Uses,Production
Biological Activity
tarafenacin is a selective antagonist of m3 muscarinic receptor with ki value of 0.19nm [1].tarafenacin is a novel quinuclidine derivative and is developed as an antimuscarinic drug for treatment of overactive bladder. it shows a 203-fold selectivity with m3 receptor over m2 receptor. tarafenacin reduces the maximum carbachol response at concentrations of 10nm and 100nm in mouse isolated bladder. in mouse atrial preparations, tarafenacin slightly attenuates the effects on heart rate caused by carbachol. tarafenacin shows a 199-fold urinary affinity against cardiac affinity. it is a highly potent antagonist in the bladder and lacks any relevant effect in atria at the same range of concentrations. in the guinea pig model, tarafenacin significantly changes the bladder contraction amplitude. it inhibits 25% of spontaneous bladder contractions at dose of 17.1nmol/kg [1].
References
[1] salcedo c, davalillo s, cabellos j, et al. in vivo and in vitro pharmacological characterization of svt-40776, a novel m3 muscarinic receptor antagonist, for the treatment of overactive bladder. british journal of pharmacology, 2009, 156(5): 807-817.
Tarafenacin Preparation Products And Raw materials
Raw materials
Preparation Products
Tarafenacin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Bsisun HK Imoprt And Export Company Limited | +86-18068513926 | China | 1280 | 55 | |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| CEG Chemical Science&Technology Co., Ltd. | Mobile:13665161512 | China | 1785 | 58 | |
| GIHI CHEMICALS CO.,LTD | 0086-571-86217390 | Sales@gihichem.com | China | 861 | 58 |