5’O-Tritylinosine
- CAS No.
- 4152-77-6
- Chemical Name:
- 5’O-Tritylinosine
- Synonyms
- KIN-59;5'-O-Trt-rI;5’O-Tritylinosine;Inosine, 5'-O-(triphenylmethyl)-;5'-O-tritylinosine-2'-deoxyinosine
- CBNumber:
- CB22701680
- Molecular Formula:
- C29H26N4O5
- Molecular Weight:
- 510.54
- MDL Number:
- MFCD29049997
- MOL File:
- 4152-77-6.mol
5’O-Tritylinosine price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19833 | KIN-59 ≥98% | 4152-77-6 | 10mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 19833 | KIN-59 ≥98% | 4152-77-6 | 50mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 19833 | KIN-59 ≥98% | 4152-77-6 | 100mg | $208 | 2024-03-01 | Buy |
| TRC | T888600 | 5’-O-Tritylinosine | 4152-77-6 | 100mg | $155 | 2021-12-16 | Buy |
| ApexBio Technology | C4148 | KIN-59 | 4152-77-6 | 50mg | $130 | 2021-12-16 | Buy |
5’O-Tritylinosine Chemical Properties,Uses,Production
Description
KIN59 is a purine riboside derivative that allosterically inhibits thymidine phosphorylase (TPase; IC50s = 44 and 67 μM for purified E. coli and human enzymes, respectively). Through this action, KIN59 blocks the conversion of thymidine to thymine. KIN59 inhibits TPase-induced angiogenesis in a chicken chorioallantoic membrane assay and reduces endothelial cell migration without impacting proliferation. KIN59 also inhibits the binding of fibroblast growth factor 2 (FGF2) to FGF receptor 1, preventing the growth and neovascularization of subcutaneous tumors induced by FGF2-transformed endothelial cells injected in immunodeficient nude mice.
Uses
5’O-Tritylinosine acts as an allosteric inhibitor of angiogenic enzyme thymidine phosphorylase.
Uses
5’-O-Tritylinosine acts as an allosteric inhibitor of angiogenic enzyme thymidine phosphorylase.
5’O-Tritylinosine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 9980 | 58 |
| Chemtour Biotech Co., Ltd | +8617327281506 | market@chemtour.com | China | 1471 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Wuhu Huaren Science and Technology Co., Ltd. | 0553-0553-5842013-801 18155347026 | sale@huarensh.com | China | 714 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55954 | 58 |
| Shanghai meikai technology co., ltd | 021-18721550-091 18721550091 | yangdong@pharma.com | China | 4123 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |