ChemicalBook >> CAS DataBase List >>1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one

1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one

1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one structure

CAS No.: 1792180-81-4

Chemical Name:: 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one

Synonyms: Ritlecitinib;PF-06651600;CS-2733;EOS-61890;Ritlecitinib (PF-06651600);PF-06651600;PF 06651600;PF06651600;Ritlecitinib free base PF-06651600;Janus kinase,Inhibitor,inhibit,PF06651600,Ritlecitinib,JAK,PF 06651600;1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2;1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one

CBNumber:: CB23142473

Molecular Formula:: C15H19N5O

Molecular Weight:: 285.34

MDL Number:: MFCD31697544

MOL File:: 1792180-81-4.mol

Last updated:2024-05-28 11:40:56

Request For Quotation

1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one Properties

Density	1.272±0.06 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO:100.0(Max Conc. mg/mL);350.4(Max Conc. mM) H2O:5.0(Max Conc. mg/mL);17.5(Max Conc. mM)
pka	13.03±0.50(Predicted)
form	powder
color	white to beige
InChI	InChI=1S/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/m0/s1
InChIKey	CBRJPFGIXUFMTM-WDEREUQCSA-N
SMILES	C(N1C[C@H](NC2N=CN=C3NC=CC3=2)CC[C@@H]1C)(=O)C=C
FDA UNII	2OYE00PC25

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PZ0316	PF-06651600 ≥98% (HPLC)	1792180-81-4	5MG	$105	2023-06-20	Buy
Sigma-Aldrich	PZ0316	PF-06651600 ≥98% (HPLC)	1792180-81-4	25MG	$339	2023-06-20	Buy
Usbiological	462323	PF-06651600	1792180-81-4	1mg	$319	2021-12-16	Buy
Usbiological	474159	PF06651600	1792180-81-4	100mg	$2315	2021-12-16	Buy
ChemScene	CS-0020243	Ritlecitinib 99.98%	1792180-81-4	5mg	$80	2021-12-16	Buy

Product number	Packaging	Price	Buy
PZ0316	5MG	$105	Buy
PZ0316	25MG	$339	Buy
462323	1mg	$319	Buy
474159	100mg	$2315	Buy
CS-0020243	5mg	$80	Buy

1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one Chemical Properties,Uses,Production

Description

Ritlecitinib, a dual JAK3/TEC inhibitor, was granted FDA breakthrough status for treating alopecia areata (autoimmune-induced hair loss) in September 2018. Promising phase 3 trial results in alopecia areata were reported by Pfizer in August 2021, placing it in competition with Lilly/Incyte’s Olumiant. It is also used in clinical studies to treat vitiligo, rheumatoid arthritis, Crohn’s disease, and ulcerative colitis. Ritlecitinib achieved high JAK3 selectivity via covalent interaction with a unique cysteine residue (Cys909) in the catalytic domain.

Characteristics

Primary targets: JAK3/TEC
Class: non-receptor tyrosine kinase
Treatment: alopecia areata (phase III)
Protein binding = 14%

Biochem/physiol Actions

PF-06651600 is a potent and selective JAK3 inhibitor.

Pharmacokinetics

Ritlecitinib exhibited low clearance in rats and dogs, contributing to its good oral bioavailability (85% in rats and 109% in dogs). Its lower oral bioavailability in monkeys (56%) primarily resulted from its fast clearance. The pharmacokinetic properties are directly linked to its stability in hepatocytes and whole blood, demonstrating the power of in vitro assays to predict in vivo pharmacokinetic parameters. The good oral bioavailability obtained from rats and dogs was a combination of high passive permeability, high aqueous solubility (>2 mg/mL), and low hepatic clearance. Ritlecitinib underwent CYP3A4-mediated oxidation of the acrylamide and piperidine ring and glutathione conjugated with the acrylamide. Allometric scaling predicted an oral bioavailability of 90% and a half-life of 2 h in humans, which need to be verified in clinical trials.

1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one Suppliers

Global( 142)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Million Pharmaceutical Co., Ltd	+86-531-68659554 +8613031714605	info@millionpharm.com	China	159	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12470	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32715	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	7154	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
NINGBOBENKANGJS PHARMTECHCO., LTD	+8615990591583 15990591583		CHINA	2029	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	6858	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58

Supplier	Advantage
Jinan Million Pharmaceutical Co., Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
Jinan Carbotang Biotech Co.,Ltd.	58
BOC Sciences	58
NINGBOBENKANGJS PHARMTECHCO., LTD	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Shanghai UCHEM Inc.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58

View Lastest Price from 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-06-12	Ritlecitinib 1792180-81-4	US $50.00 / g	10g	99%	10KG/M	Jinan Million Pharmaceutical Co., Ltd
2024-04-23	1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one 1792180-81-4	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2023-09-14	Ritlecitinib 1792180-81-4	US $0.00-0.00 / g	100g	99%	20 tons	Wuhan Han Sheng New Material Technology Co.，Ltd

Ritlecitinib
1792180-81-4
US $50.00 / g
99%
Jinan Million Pharmaceutical Co., Ltd

1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
1792180-81-4
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

Ritlecitinib
1792180-81-4
US $0.00-0.00 / g
99%
Wuhan Han Sheng New Material Technology Co.，Ltd

1792180-81-4(1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one)Related Search:

PF-06700841 tosylate PF-06650833 PF-06447475 Lorlatinib (PF-06463922) 3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-N-(2-pyridinylmethyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridine-7-methanesulfonamide

2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID Upadacitinib Q-VD-OPh hydrate N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide H3B-6527

Senexin B 2-(2-((4-bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide (S)-4-(4-((2-(3,5-diMethylphenyl)pyrrolidin-1-yl)Methyl)phenoxy)-3-fluorobenzaMide BMS-986205 Budiodarone tartrate

COH-29

1of4

1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one EOS-61890 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2 CS-2733 PF-06651600;PF 06651600;PF06651600 1-[(2S,5R)-2-methyl-5(7H-pyrrolo[2,3-d]pyrimidine-4-ylamino)-1-piperidinly]-2-propen-1-one malonate,PF06651600 2-Propen-1-one, 1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]- 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one PF-06651600 Ritlecitinib Ritlecitinib (PF-06651600) Janus kinase,Inhibitor,inhibit,PF06651600,Ritlecitinib,JAK,PF 06651600 1-[(2S,5R)-5-[[7H-Pyrrolo[2,3-d]-4-pyrimidinyl]amino]-2-methyl-1-piperidyl]-2-propen-1-one Ritlecitinib free base PF-06651600 1792180-81-4 API 1