ChemicalBook >> CAS DataBase List >>(R)-(+)-WARFARIN
(R)-(+)-WARFARIN
- CAS No.
- 5543-58-8
- Chemical Name:
- (R)-(+)-WARFARIN
- Synonyms
- (R)-WARFARIN;Dextrowarfarin;(R)-(+)-WARFARIN;Warfarin R-Isomer;Warfarin Impurity 16;Warfarin Impurity 16（Warfarin R-Isomer）;r-(+)-3-acetonybenzyl)-4-hydroxycoumarin;R-(+)-3-(ACETONYLBENZYL)-4-HYDROXYCOUMARIN;(S)-3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin;(+)-3-[(R)-α-Acetonylbenzyl]-4-hydroxycoumarin
- CBNumber:
- CB2351124
- Molecular Formula:
- C19H16O4
- Molecular Weight:
- 308.33
- MDL Number:
- MFCD00272376
- MOL File:
- 5543-58-8.mol
Last updated:2023-06-08 09:02:11
| Melting point | ≥170 °C |
|---|---|
| Boiling point | 515.2±50.0 °C(Predicted) |
| Density | 1.307±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF: soluble |
| form | A crystalline solid |
| pka | 4.50±1.00(Predicted) |
| color | white to pale yellow |
| FDA UNII | 09CC5J5C8A |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330-H360D-H372-H411 | |||||||||
| Precautionary statements | P202-P264-P273-P280-P302+P352+P310-P304+P340+P310 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 61-48/25-52/53 | |||||||||
| Safety Statements | 53-45-61 | |||||||||
| RIDADR | UN 2811 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
(R)-(+)-WARFARIN price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | UC213 | (R)-(+)-Warfarin ≥97% (HPLC) | 5543-58-8 | 10mg | $1520 | 2022-05-15 | Buy |
| Cayman Chemical | 13526 | (+)-Warfarin ≥98% | 5543-58-8 | 1mg | $77 | 2024-03-01 | Buy |
| Cayman Chemical | 13526 | (+)-Warfarin ≥98% | 5543-58-8 | 5mg | $211 | 2024-03-01 | Buy |
| Cayman Chemical | 13526 | (+)-Warfarin ≥98% | 5543-58-8 | 10mg | $383 | 2024-03-01 | Buy |
| Cayman Chemical | 13526 | (+)-Warfarin ≥98% | 5543-58-8 | 25mg | $861 | 2024-03-01 | Buy |
(R)-(+)-WARFARIN Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
The R-(+)-form of Warfarin (W498500). Coumarin anticoagulant.
Uses
(R)-(+)-warfarin has been used to investigate whether enantiomers of warfarin stereoselectively interact with pregnane X nuclear receptor (PXR) to upregulate main drug/xenobiotic-metabolizing enzymes cytochrome P450 3A4 (CYP3A4) and cytochrome P450 2C9 (CYP2C9). It has also been used in HepG2 cells to study protein profiles
Definition
ChEBI: (R)-warfarin is a 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one that has (R)-configuration (the racemate is warfarin, an anticoagulant drug and rodenticide). It is a conjugate acid of a (R)-warfarin(1-). It is an enantiomer of a (S)-warfarin.
General Description
The chiral carbon at position 9 produces two enantiomers, R- and S-warfarin. Commercially available warfarin (Coumadin or Jantoven) is a racemic mixture of S- and R-enantiomers.
Biochem/physiol Actions
Warfarin acts as a vitamin K antagonist. It is widely used to treat thromboembolic disorders. (R)-warfarin interacts with pregnane X receptor (PXR) and induces cytochrome P450 3A4 (CYP3A4) and CYP2C9 mRNAs expression in primary human hepatocyte cultures.
(R)-(+)-WARFARIN Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-(+)-WARFARIN Suppliers
Global( 56)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Hebei Duling International Trade Co. LTD | +8618712993135 | sales01@hbduling.cn | China | 15743 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 6854 | 65 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9685 | 58 |
| Cato Research Chemicals Inc. | 020-81960175 | min.he@cato-chem.com | China | 1958 | 55 |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | greensnown@163.com | China | 9911 | 50 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
5543-58-8((R)-(+)-WARFARIN)Related Search:
Warfarin
4-Hydroxycoumarin
4,4'-(Disulfanediyl)bis(2,6-di-tert-butylphenol)
(S)-8-Hydroxy Warfarin
(R)-6-Hydroxy Warfarin
3-(o-Hydroxyphenyl)-5-phenyl-2-cyclohexen-1-one
Benzalacetone
3-[α-(2-Hydroxypropyl)benzyl]-4-hydroxycouMarin
(R)-7-Hydroxy Warfarin
(S)-6-Hydroxy Warfarin
1of4
4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one
(R)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone
(S)-3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin
r-(+)-3-acetonybenzyl)-4-hydroxycoumarin
2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, (R)-
2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]- (9CI)
Coumarin, 3-(a-acetonylbenzyl)-4-hydroxy-, R-(+)- (8CI)
Dextrowarfarin
R-(+)-3-Acetonybenzyl)-4-hydroxycoumarin, R-(+)-4-Hydroxy-3-(3-oxo-1-phenybutyl)-2H-1-benzopyran-2-one
(+)-3-[(R)-1-Phenyl-3-oxobutyl]-4-hydroxycoumarin
(+)-3-[(R)-α-Acetonylbenzyl]-4-hydroxycoumarin
(+)-4-Hydroxy-3-[(R)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one
2-hydroxy-3-[(1R)-3-keto-1-phenyl-butyl]chromone
2-hydroxy-3-[(1R)-3-oxo-1-phenyl-butyl]chromen-4-one
2-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]chromen-4-one
R-(+)-4-HYDROXY-3-(3-OXO-1-PHENYBUTYL)-2H-1-BENZOPYRAN-2-ONE
(R)-(+)-4-HYDROXY-3-(3-OXO-1-PHENYLBUTYL)-2H-1-BENZOPYRAN-2-ONE
R-(+)-3-(ACETONYLBENZYL)-4-HYDROXYCOUMARIN
(R)-(+)-WARFARIN
(R)-WARFARIN
(R)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
(R)-(+)-WarfarinQ: What is
(R)-(+)-Warfarin Q: What is the CAS Number of
(R)-(+)-Warfarin Q: What is the storage condition of
(R)-(+)-Warfarin
Warfarin R-Isomer
2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-
Warfarin Impurity 16（Warfarin R-Isomer）
Warfarin Impurity 16
5543-58-8
Aromatics
Chiral Reagents
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals