Gabapentin-lactam
- CAS No.
- 64744-50-9
- Chemical Name:
- Gabapentin-lactam
- Synonyms
- Gabapentin Related Compound A;3,3-PENTAMETHYLENE-4-BUTYROLACTAM;forgabapentine;Gabapentin RC A;Gabapentin-lactam;Gabapentin Lactum;Gabapentin USP RC A;Gabapentin EP Impurity A;Gabapentin impurity A CRS;3-AZASPIRO[4.5]DECAN-2-ONE
- CBNumber:
- CB2415644
- Molecular Formula:
- C9H15NO
- Molecular Weight:
- 153.22
- MDL Number:
- MFCD00177938
- MOL File:
- 64744-50-9.mol
- MSDS File:
- SDS
| Melting point | 84-89 °C(lit.) |
|---|---|
| Boiling point | 181 °C / 13mmHg |
| Density | 1.05±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 40 mg/ml) |
| pka | 16.39±0.20(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| InChIKey | JAWPQJDOQPSNIQ-UHFFFAOYSA-N |
| CAS DataBase Reference | 64744-50-9(CAS DataBase Reference) |
| FDA UNII | 0IP6953295 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | CM0120000 |
| HazardClass | IRRITANT |
| HS Code | 29337900 |
Gabapentin-lactam price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 553743 | 4,4-Pentamethylene-2-pyrrolidinone 96% | 64744-50-9 | 25g | $209 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1287325 | Gabapentin Related Compound A United States Pharmacopeia (USP) Reference Standard | 64744-50-9 | 50mg | $1380 | 2024-03-01 | Buy |
| TCI Chemical | P1695 | 4,4-Pentamethylene-2-pyrrolidone >98.0%(GC) | 64744-50-9 | 5g | $39 | 2024-03-01 | Buy |
| TCI Chemical | P1695 | 4,4-Pentamethylene-2-pyrrolidone >98.0%(GC) | 64744-50-9 | 25g | $114 | 2024-03-01 | Buy |
| Sigma-Aldrich | Y0001281 | Gabapentin impurity A European Pharmacopoeia (EP) Reference Standard | 64744-50-9 | y0001281 | $153 | 2024-03-01 | Buy |
Gabapentin-lactam Chemical Properties,Uses,Production
Description
Gabapentin lactam (CAS 64744-50-9) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease.1 Displays neurotrophic effects, enhancing the formation of dendritic filopodia and inducing a network of F-actin-containing neurites in cultured hippocampal neurons.2 Promotes the survival of cultured central nervous system neurons possibly by opening mitochondrial KATP channels.3 Displays neuroprotective effects in a rat model of acute retinal ischemia.4
Chemical Properties
Gabapentin-lactam is White Solid
Uses
Gabapentin-lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.
Uses
Gabapentin Lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington disease. It opens mitochondrial ATP-dependent potassium channels
Uses
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Definition
ChEBI: 2-Azaspiro[4.5]decan-3-one is an azaspiro compound.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
References
1) Zucker et al. (2004), Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in transgenic mouse model of huntington’s disease; Nauyn Schmiedebergs Arch. Pharmacol., 370 131 2) Henle et al. (2006), Gabapentin-lactam induces dendritic filopodia and motility in cultured hippocampal neurons; J. Pharmacol. Exp. Ther., 319 181 3) Pielen et al. (2004), Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels; Graefes Arch. Clin. Exp. Ophthalmol., 242 240 4) Lagreze et al. (2001), The neuroprotective properties of gabapentin-lactam; Graefes Arch. Clin. Exp. Ophthalmol., 239 845
Gabapentin-lactam Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12471 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
View Lastest Price from Gabapentin-lactam manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-01-31 | Gabapentin-Lactam
64744-50-9
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2022-11-23 | Trimethyl phosphonoacetate
64744-50-9
|
US $1.00 / kg | 1kg | 99% | 10000 | Hebei Duling International Trade Co. LTD | |
 |
2022-05-11 | Gabapentin-Lactam
64744-50-9
|
US $0.00 / g | 10g | 99.0% | 10tons | Wuhan Godbullraw Chemical Co.,ltd |
-
- Gabapentin-Lactam
64744-50-9
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Trimethyl phosphonoacetate
64744-50-9
- US $1.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD
-
- Gabapentin-Lactam
64744-50-9
- US $0.00 / g
- 99.0%
- Wuhan Godbullraw Chemical Co.,ltd