Lisinopril Dihydrate
- CAS No.
- 83915-83-7
- Chemical Name:
- Lisinopril Dihydrate
- Synonyms
- Lisinopril;Zestfil;renacor;isinopriL;Lisinopril API;(S) Lisinopril;L-154826：MK-521;LISINOPRIL HYDRATE;Lisinopril99%Assay;MK-521 (dihydrate)
- CBNumber:
- CB3113756
- Molecular Formula:
- C21H33N3O6
- Molecular Weight:
- 423.51
- MDL Number:
- MFCD08064198
- MOL File:
- 83915-83-7.mol
- MSDS File:
- SDS
| Melting point | 148 °C |
|---|---|
| alpha | 25405 -120° (c = 1 in 0.25M pH 6.4 zinc acetate); 25436 -96° (c = 1 in 0.25M pH 6.4 zinc acetate) |
| refractive index | -45 ° (C=1, 0.25mol/L Zinc Acetate Buffer) |
| storage temp. | 2-8°C |
| solubility | H2O: ≥10 mg/mL |
| pka | 2.5, 4.0, 6.7, 10.1(at 25℃) |
| form | solid |
| color | white |
| Merck | 14,5516 |
| Stability | Hygroscopic |
| CAS DataBase Reference | 83915-83-7(CAS DataBase Reference) |
| FDA UNII | E7199S1YWR |
| NCI Dictionary of Cancer Terms | lisinopril |
| NCI Drug Dictionary | lisinopril |
| ATC code | C09AA03 |
| EPA Substance Registry System | L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, hydrate (1:2) (83915-83-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360D-H373 |
| Precautionary statements | P202-P260-P280-P308+P313-P405-P501 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 20/21/22 |
| Safety Statements | 22-24/25-36 |
| WGK Germany | 3 |
| RTECS | TW3589990 |
| HazardClass | IRRITANT |
| HS Code | 2933995300 |
Lisinopril Dihydrate price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L6292 | Lisinopril ≥98% (HPLC) | 83915-83-7 | 100mg | $401 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP695 | Lisinopril dihydrate British Pharmacopoeia (BP) Reference Standard | 83915-83-7 | 100MG | $262 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1368609 | Lisinopril United States Pharmacopeia (USP) Reference Standard | 83915-83-7 | 300mg | $436 | 2024-03-01 | Buy |
| TCI Chemical | L0220 | Lisinopril Dihydrate >98.0%(T) | 83915-83-7 | 1g | $100 | 2024-03-01 | Buy |
| TCI Chemical | L0220 | Lisinopril Dihydrate >98.0%(T) | 83915-83-7 | 5g | $299 | 2024-03-01 | Buy |
Lisinopril Dihydrate Chemical Properties,Uses,Production
Description
Lisinopril is an angiotensin converting enzyme inhibitor structurally related to enalaprilat. It is reportedly useful in the management of hypertension and congestive heart failure.
Chemical Properties
White to Off-White Crystalline Powder
Originator
Merck (USA)
Uses
An orally active angiotensin-converting enzyme (ACE) inhibitor. S,S,S-Isomer of Lisinopril.
Uses
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Definition
ChEBI: Lisinopril dihydrate is a hydrate. It has a role as an antihypertensive agent. It contains a lisinopril.
brand name
Prinivil (Merck); Zestril (AstraZeneca).
General Description
Lisinopril, 1-[N2-[S-1-carboxy-3-phenylpropyl]-L-lysyl]-L-proline dihydrate (Prinivil, Zestril), is alysine derivative of enalaprilat, the active metabolite ofenalapril. Like all ACE inhibitors, it is an active site-directedinhibitor of the enzyme, with the zinc ion used in an effectivebinding interaction at a stoichiometric ratio of 1:1. The pharmacologicaleffects of lisinopril are similar to those of captopriland enalapril.
Biochem/physiol Actions
Angiotensin converting enzyme (ACE) inhibitor.
Clinical Use
Many new ACE inhibitors became available for the treatmentof hypertension following the clinical effectivenessof enalapril. Enalapril is a non–thiol-containing ACE inhibitordevoid of the side effects of rash and loss of thesense of taste characteristic of the thiol-containing compoundcaptopril. With the exception of the phosphoruscontainingfosinopril, these antihypertensive agents havea 2-, like the prototypical drug captopril,are used in the treatment of mild-to-moderate hypertension,either alone or in conjunction with diuretics orcalcium channel blockers.
Veterinary Drugs and Treatments
The principle uses of lisinopril in veterinary medicine at present are
as a vasodilator
in the treatment of heart failure or hypertension.
Recent studies have demonstrated that ACE inhibitors, particularly
when used in conjunction with furosemide, do improve the quality
of life in dogs with heart failure. It is not clear, however, whether it
has any significant effect
on survival times. Lisinopril may also be of
benefit in treating the effects associated with valvular heart disease
(mitral regurgitation) and left to right shunts. It is being explored
as adjunctive treatment in chronic renal failure and in protein losing
nephropathies.
Lisinopril may have advantages over other ACE inhibitors in
that it may be dosed once daily and less expensive. Disadvantages
are that it is only available in human labeled dosage forms and there
is much less published information on its use (efficacy, safety, dosing)
in veterinary species.
Lisinopril Dihydrate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou ICH Biofarm Co., Ltd | +undefined8613073685410 | sales@ichemie.com | China | 985 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 16801 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 952 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 1094 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
View Lastest Price from Lisinopril Dihydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-14 | Lisinopril
83915-83-7
|
US $30.00 / g | 10g | 98% | 2000kg | hebei hongtan Biotechnology Co., Ltd | |
 |
2024-04-25 | Lisinopril
83915-83-7
|
US $1.00 / g | 1g | 99 | 20tons | Shanghai Longyu Biotechnology Co., Ltd. | |
 |
2024-04-16 | Lisinopril Dihydrate
83915-83-7
|
US $36.00-1.20 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- Lisinopril
83915-83-7
- US $30.00 / g
- 98%
- hebei hongtan Biotechnology Co., Ltd
-
- Lisinopril
83915-83-7
- US $1.00 / g
- 99
- Shanghai Longyu Biotechnology Co., Ltd.
-
- Lisinopril Dihydrate
83915-83-7
- US $36.00-1.20 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
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