Rizatriptan
- CAS No.
- 144034-80-0
- Chemical Name:
- Rizatriptan
- Synonyms
- CS-281;RIZATRIPTAN;Rizatriptan-d3;Rizatriptan USP/EP/BP;Rizatriptan###144034-80-0;2-(5-((1H-1,2,4-Triazol-1-yl);Acetochlor Impurity 3 (Butachlor);N,N-Dimethyl-5-(1H-1,2,4-trizol-1-ylmethyl)-1H-indole-3-ethanamine;n,n-dimethyl-5-(1h-1,2,4-triazol-1-ylmethyl)-1h-indole-3-ethanamine;1H-Indole-3-ethanaMine,N,N-diMethyl-5-(1H-1,2,4-triazol-1-ylMethyl)-
- CBNumber:
- CB3245026
- Molecular Formula:
- C15H19N5
- Molecular Weight:
- 269.34
- MDL Number:
- MFCD03840591
- MOL File:
- 144034-80-0.mol
- MSDS File:
- SDS
| Melting point | 178-180°C |
|---|---|
| Boiling point | 504.8±60.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 16.98±0.30(Predicted) |
| Water Solubility | 42 mg/mL |
| CAS DataBase Reference | 144034-80-0(CAS DataBase Reference) |
| FDA UNII | 51086HBW8G |
| ATC code | N02CC04 |
| EPA Substance Registry System | Acetonitrile, 2,2-dibromo-2-chloro- (144034-80-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H319-H361-H372-H336 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P201-P202-P281-P308+P313-P405-P501-P260-P264-P270-P314-P501-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
Rizatriptan price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 076042 | 2-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethanamine 95+% | 144034-80-0 | 250mg | $260 | 2021-12-16 | Buy |
| Matrix Scientific | 076042 | 2-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethanamine 95+% | 144034-80-0 | 1g | $559 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0006958 | RIZATRIPTAN 95.00% | 144034-80-0 | 1G | $1191.96 | 2021-12-16 | Buy |
| AvaChem | 2800B | Rizatriptan | 144034-80-0 | 10g | $1490 | 2021-12-16 | Buy |
| Arctom | AS008491 | Rizatriptan ≥98% | 144034-80-0 | 1g | $478 | 2021-12-16 | Buy |
Rizatriptan Chemical Properties,Uses,Production
Uses
Ca channel blocker
Uses
Rizatriptan is reported to be a very effective acute migraine drug. It is reported to display high agonist activity at mainly the serotonin 5-HT1B and 5-HT1D receptor subtypes.
Definition
ChEBI: Rizatriptan is a member of tryptamines. It has a role as a serotonergic agonist, a vasoconstrictor agent and an anti-inflammatory drug. It is functionally related to a N,N-dimethyltryptamine.
brand name
Maxalt (Merck).
General Description
Rizatriptan, approved in 1998, is a fast-acting triptan becauseof its moderate lipophilicity yet has a very shortelimination half-life similar to sumatriptan (i.e., like sumatriptan,it is mainly metabolized by MAO-A). The only advantagesof this drug when compared with sumatriptan arethat it has a slightly faster onset and that it has an orallydisintegrating tablet formulation which can be taken withoutwater.
Clinical Use
5HT1
receptor agonist:
Acute treatment of migraine
Drug interactions
Potentially hazardous interactions with other drugs
Antidepressants: increased risk of CNS excitation
with citalopram - avoid; risk of CNS toxicity
with MAOIs, moclobemide and linezolid - avoid
for 2 weeks after discontinuation of MAOI and
moclobemide; possibly increased serotonergic
effects with duloxetine and venlafaxine; increased
serotonergic effects with St John’s wort - avoid.
Dapoxetine: possible increased risk of serotonergic
effects - avoid for 2 weeks after stopping 5HT1
agonists.
Ergot alkaloids: increased risk of vasospasm - avoid.
Propranolol: rizatriptan levels increased, reduce dose
of rizatriptan to 5 mg (max 10 mg in 24 hours).
Metabolism
The main route of rizatriptan metabolism is via oxidative
deamination by monoamine oxidase-A (MAO-A)
to the indole acetic acid metabolite, which is not
pharmacologically active. N-monodesmethyl-rizatriptan,
a metabolite with activity similar to that of parent
compound, is formed to a minor degree, but does not
contribute significantly to the pharmacodynamic activity
of rizatriptan.
Less than 1% is excreted in the urine as active
N-monodesmethyl metabolite.
Rizatriptan Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1320 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3386 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
View Lastest Price from Rizatriptan manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-13 | Rizatriptan
144034-80-0
|
US $0.00-0.00 / mg | 10mg | 0.98 | 10g | ShenZhen H&D Pharmaceutical Technology Co., LTD | |
 |
2024-05-10 | Rizatriptan
144034-80-0
|
US $0.00-0.00 / mg | 10mg | 0.98 | 10g | ShenZhen H&D Pharmaceutical Technology Co., LTD | |
 |
2023-06-26 | Rizatriptan
144034-80-0
|
US $200.00 / kg | 1kg | 99% | 1000kg/Month | Hebei Mingeng Biotechnology Co., Ltd |
-
- Rizatriptan
144034-80-0
- US $0.00-0.00 / mg
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
-
- Rizatriptan
144034-80-0
- US $0.00-0.00 / mg
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
-
- Rizatriptan
144034-80-0
- US $200.00 / kg
- 99%
- Hebei Mingeng Biotechnology Co., Ltd