Disopyramide
- CAS No.
- 373-79-5
- Chemical Name:
- Disopyramide
- Synonyms
- CBNumber:
- CB32486694
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| FDA UNII | GFO928U8MQ |
|---|
Disopyramide Chemical Properties,Uses,Production
Clinical Use
Ventricular and supraventricular arrhythmias
Drug interactions
Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased myocardial depression
with other anti-arrhythmics; amiodarone and
dronedarone increase risk of ventricular arrhythmias
- avoid.
Antibacterials: concentration possibly increased by
azithromycin, clarithromycin and erythromycin (risk
of toxicity); increased risk of ventricular arrhythmias
with moxifloxacin - avoid; possibly increased risk
of ventricular arrhythmias with telithromycin and
delamanid; concentration reduced by rifamycins.
Antidepressants: increased risk of ventricular
arrhythmias with tricyclics; increased risk of
ventricular arrhythmias with citalopram and
escitalopram - avoid.
Antifungals: increased risk of ventricular
arrhythmias with ketoconazole - avoid; avoid with
itraconazole.
Antihistamines: increased risk of ventricular
arrhythmias with mizolastine.
Antihypertensives: increased myocardial depression
and asystole with beta-blockers or verapamil;
increased risk of ventricular arrhythmias with sotalol
Antimuscarinics: increased risk of antimuscarinic
side effects; increased risk of ventricular arrhythmias
with tolterodine.
Antivirals: concentration possibly increased by
ritonavir, increased risk of toxicity; increased risk
- avoid.
Metabolism
Disopyramide is partially metabolised in the liver by the cytochrome P450 isoenzyme CYP3A4. The major metabolite is mono-N-dealkylated disopyramide which retains some antiarrhythmic and antimuscarinic activity. The major route of excretion is through the kidney, about 50-60% as the unchanged drug, 20% as the N-dealkylated metabolite, and 10% as other metabolites. 64% of the N-dealkylated metabolite is excreted via the faeces.