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JZL 195

CAS No.
1210004-12-8
Chemical Name:
JZL 195
Synonyms
CS-1586;JZL 195;JZL-195;JZL 195;JZL195;4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate;4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]-1-piperazinecarboxylate;4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester;1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester;Autophagy,Monoacylglycerol lipase,inhibit,MAGL,Fatty acid amide hydrolase,JZL-195,JZL195,Inhibitor,FAAH,JZL 195
CBNumber:
CB32591530
Molecular Formula:
C24H23N3O5
Molecular Weight:
433.46
MDL Number:
MFCD18382122
MOL File:
1210004-12-8.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

JZL 195 Properties

Boiling point 581.8±50.0 °C(Predicted)
Density 1.303±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO: ≥5mg/mL at warmed
pka 6.13±0.10(Predicted)
form powder
color white to beige
FDA UNII TP6P2HKJ54

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS09
Signal word  Warning
Hazard statements  H400
Precautionary statements  P273
Hazard Codes  N
Risk Statements  50
Safety Statements  61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3

JZL 195 price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0257 JZL195 ≥98% (HPLC) 1210004-12-8 5mg $127 2024-03-01 Buy
Sigma-Aldrich SML0257 JZL195 ≥98% (HPLC) 1210004-12-8 25mg $491 2024-03-01 Buy
Cayman Chemical 13668 JZL 195 ≥98% 1210004-12-8 5mg $61 2024-03-01 Buy
Cayman Chemical 13668 JZL 195 ≥98% 1210004-12-8 10mg $112 2024-03-01 Buy
Cayman Chemical 13668 JZL 195 ≥98% 1210004-12-8 50mg $468 2024-03-01 Buy
Product number Packaging Price Buy
SML0257 5mg $127 Buy
SML0257 25mg $491 Buy
13668 5mg $61 Buy
13668 10mg $112 Buy
13668 50mg $468 Buy

JZL 195 Chemical Properties,Uses,Production

Description

Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50s = 2 and 4 nM, respectively). It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation. The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 and JZL 184 , respectively. Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB1 agonists.

Uses

JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.

storage

Store at -20°C

JZL 195 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 80)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32715 60
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652 info@fdachem.com China 18214 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131980 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2923 55

View Lastest Price from JZL 195 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JZL 195 pictures 2020-03-06 JZL 195
1210004-12-8
US $1.00 / KG 1KG 97%-99.9% 100kg Career Henan Chemical Co
  • JZL 195 pictures
  • JZL 195
    1210004-12-8
  • US $1.00 / KG
  • 97%-99.9%
  • Career Henan Chemical Co
JZL 195 4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester CS-1586 JZL-195;JZL 195;JZL195 1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester 4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]-1-piperazinecarboxylate Autophagy,Monoacylglycerol lipase,inhibit,MAGL,Fatty acid amide hydrolase,JZL-195,JZL195,Inhibitor,FAAH,JZL 195 1210004-12-8 Inhibitors API