Vorapaxar
- CAS No.
- 618385-01-6
- Chemical Name:
- Vorapaxar
- Synonyms
- MK-5348;[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-Fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-carbamic acid ethyl ester;CS-2015;CS-1663;Vorapaxar;Voarapaxar;2H5]-Vorapaxar;7-Dihydrocapsaicin;Vorapaxar free base;Vorapaxar (MK-5348)
- CBNumber:
- CB32628522
- Molecular Formula:
- C29H33FN2O4
- Molecular Weight:
- 492.58
- MDL Number:
- MFCD16038876
- MOL File:
- 618385-01-6.mol
| Boiling point | 676.0±55.0 °C(Predicted) |
|---|---|
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20° C |
| solubility | ≥24.65 mg/mL in DMSO; insoluble in H2O; ≥10.64 mg/mL in EtOH with ultrasonic |
| form | solid |
| pka | 12.49±0.60(Predicted) |
| FDA UNII | ZCE93644N2 |
| ATC code | B01AC26 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H371-H410-H373-H400 | |||||||||
| Precautionary statements | P273-P391-P501-P273-P391-P501-P260-P314-P501-P260-P264-P270-P309+P311-P405-P501 | |||||||||
| NFPA 704 |
|
Vorapaxar price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23119 | Vorapaxar ≥98% | 618385-01-6 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 23119 | Vorapaxar ≥98% | 618385-01-6 | 5mg | $208 | 2024-03-01 | Buy |
| ApexBio Technology | A8809 | Vorapaxar | 618385-01-6 | 10mg | $252 | 2021-12-16 | Buy |
| AK Scientific | J96880 | Vorapaxar | 618385-01-6 | 10mg | $288 | 2021-12-16 | Buy |
| ChemScene | CS-5527 | Vorapaxar 99.85% | 618385-01-6 | 10mg | $288 | 2021-12-16 | Buy |
Vorapaxar Chemical Properties,Uses,Production
Description
Vorapaxar is an orally bioavailable competitive antagonist of the proteinase-activated receptor (PAR1; Ki = 8.1 nM), also known as the thrombin receptor. It is selective for PAR1 over other PARs, as well as a number of GPCRs, ion channels, and receptors. It inhibits platelet aggregation induced by thrombin and haTRAP (IC50s = 47 and 25 nM, respectively). Vorapaxar (0.1 mg/kg, i.v.) completely inhibits platelet aggregation in cynomolgus monkeys ex vivo. Formulations containing vorapaxar are used in the prevention of thrombotic cardiovascular events.
Definition
ChEBI: A carbamate ester that is the ethyl ester of [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethyny }-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamic acid. A protease-activated receptor-1 antagonist used (as its sulfate salt) for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction MI) or with peripheral arterial disease. It has been shown to reduce the rate of a combined endpoint of cardiovascular death, MI, stroke and urgent coronary revascularisation.
References
[1]. chackalamannil s & xia, y. thrombin receptor (par-1) antagonists as novel antithrombotic agents. expert opinion on therapeutic patents, 2006.16:493-505.
[2]. chackalamannil s, wang y, greenlee w j et al. 2008. discovery of a novel, orally active himbacine-based thrombin receptor antagonist (sch 530348) with potent antiplatelet activity. j med chem, 2008,51: 3061-3064.
Vorapaxar Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21688 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4022 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15377 | 58 |
| XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 | sales06@tgybio.com | China | 937 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
