LDN-211904
- CAS No.
- 1198408-78-4
- Chemical Name:
- LDN-211904
- Synonyms
- LDN-211904 Oxalate;LDN-211904 Oxalate 3-(4'-(dimethylamino)biphenyl-3-yl)-1,1-dimethylurea;N-(2-Chlorophenyl)-6-(4-piperidinyl)tmidazo[1,2-a]pyridine-3-carboxamideethanedioate;N-(2-Chlorophenyl)-6-(4-piperidinyl)tmidazo[1,2-a]pyridine-3-carboxamide ethanedioate (1:1)
- CBNumber:
- CB33033147
- Molecular Formula:
- C21H21ClN4O5
- Molecular Weight:
- 444.86824
- MDL Number:
- MOL File:
- 1198408-78-4.mol
LDN-211904 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20453 | LDN-211904 ≥98% | 1198408-78-4 | 1mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 20453 | LDN-211904 ≥98% | 1198408-78-4 | 5mg | $219 | 2024-03-01 | Buy |
| ApexBio Technology | C4541 | LDN-211904 | 1198408-78-4 | 5mg | $221 | 2021-12-16 | Buy |
| ApexBio Technology | C4541 | LDN-211904 | 1198408-78-4 | 10mg | $374 | 2021-12-16 | Buy |
| AK Scientific | 8636DG | Ldn-211904oxalate | 1198408-78-4 | 1mg | $174 | 2021-12-16 | Buy |
LDN-211904 Chemical Properties,Uses,Production
Biological Activity
ldn-211904 is an inhibitor of erythropoietin-producing hepatocellular carcinoma (eph) receptors.erythropoietin-producing hepatocellular carcinoma (eph) receptors, a group of highly conserved transmembrane proteins composed of multiple domains, participate in various cell signaling pathways. so far, 16 eph receptors have been identified in vertebrates, which can be divided into two major classes (epha and ephb) based on sequence similarity. mammals including humans have 14 eph receptors (epha1–epha8, epha10, ephb1–ephb4 and ephb6).
in vitro
previous study found that ldn-211904, a 4-piperidinyl analog, retained significant ephb3 inhibitory activity, and also had greater aqueous solubility due to the presence of a basic amine. ldn-211904 was profiled for functional inhibitory activity against a panel of 288 kinases and the results showed that ldn-211904 was quite selective for tyrosine kinases. the only noted exceptions were the three serine/threonine kinases p38a, p38b, and qik. in addition, only ldn-211904 showed moderate selectivity among the tyrosine kinases and little selectivity verses other epha and ephb subtypes, except for epha6 and epha7. moreover, ldn-211904 demonstrated the best stability with a t1/2 of 348 min and a clint of 4 μl/min/mg protein [1].
IC 50
79 nm for ephb3
References
[1] qiao, l. ,choi, s.,case, a., et al. structure-activity relationship study of ephb3 receptor tyrosine kinase inhibitors. bioor. med. chem. lett. 19(21), 6122-6126 (2009).
LDN-211904 Preparation Products And Raw materials
Raw materials
Preparation Products
LDN-211904 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4691 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 18087 | 64 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2985 | 58 |