Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>DE-7

DE-7

DE-7 Structure
DE-7 structure
CAS No.
681490-93-7
Chemical Name:
DE-7
Synonyms
DE-7;Dilamanid intermediate;2-Chloro-1-[[(2R)-2-methyloxiranyl]methyl]-4-nitro-1H-imidazole;(R)-2-chloro-1-{(2-methyloxiran-2-yl)methyl}-4-nitro-1H-imidazole;1H-Imidazole, 2-chloro-1-[[(2R)-2-methyl-2-oxiranyl]methyl]-4-nitro-
CBNumber:
CB33154114
Molecular Formula:
C7H8ClN3O3
Molecular Weight:
217.61
MDL Number:
MOL File:
681490-93-7.mol
MSDS File:
SDS
Last updated:2023-04-23 13:52:06
Request For Quotation

DE-7 Properties

Melting point 72-73 °C
Boiling point 393.9±38.0 °C(Predicted)
Density 1.68±0.1 g/cm3(Predicted)
solubility Chloroform, DCM
form Solid
pka -2.55±0.60(Predicted)
color Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Danger
Hazard statements  H312-H303-H315-H319-H361-H372-H317-H351-H335-H336-H412
Precautionary statements  P501-P273-P272-P260-P270-P202-P201-P271-P264-P280-P312-P337+P313-P305+P351+P338-P362+P364-P333+P313-P302+P352+P312-P304+P340+P312-P403+P233-P405

DE-7 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C380575 2-Chloro-1-[[(2R)-2-methyloxiranyl]methyl]-4-nitro-1H-imidazole 681490-93-7 25mg $635 2021-12-16 Buy
TRC C380575 2-Chloro-1-[[(2R)-2-methyloxiranyl]methyl]-4-nitro-1H-imidazole 681490-93-7 100mg $1925 2021-12-16 Buy
Medical Isotopes, Inc. 44628 2-Chloro-1-[[(2R)-2-methyloxiranyl]methyl]-4-nitro-1H-imidazole 681490-93-7 100mg $2750 2021-12-16 Buy
Product number Packaging Price Buy
C380575 25mg $635 Buy
C380575 100mg $1925 Buy
44628 100mg $2750 Buy

DE-7 Chemical Properties,Uses,Production

Uses

2-Chloro-1-[[(2R)-2-methyloxiranyl]methyl]-4-nitro-1H-imidazole is an intermediate in the synthesis of Delamanid (D230660), a novel anti-tuberculosis medication that inhibits mycolic acid synthesis and shows potent in-vitro and in-vivo activity against drug-resistant strains of Mycobacterium tuberculosis.

DE-7 synthesis

683276-63-3
57531-37-0
681490-93-7
Synthesis of DE-7 from DE-6 and 2-Chloro-4-nitroimidazole

DE-7 Preparation Products And Raw materials

Raw materials

2-Chloro-4-nitroimidazole DE-6 (R)-3-(2-chloro-4-nitro-1H-imidazol-1-yl)-2-hydroxy-2-methylpropylmethanesulfonate (R)-2-chloro-1-(2,3-dihydroxy-2-methyl)-propyl-4-nitroimidazole (R)-2-chloro-1-[2-hydroxy-2-methyl-3-(4-nitrobenzoyloxy)]-propyl-4-nitroimidazole

Preparation Products

DE-7 Suppliers

Global( 16)Suppliers
Supplier Tel Email Country ProdList Advantage
CD Chemical Group Limited 		+8615986615575 info@codchem.com China 20356 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131980 58
Chemipanda Bio-Tech Co., Ltd. +86-571-85224801; 13588483690 chemipanda2010@163.com China 110 62
Lynnchem 86-(0)29-85992781 17792393971 info@lynnchem.com China 4587 58
Novachemistry 44-20819178-90 02081917890 info@novachemistry.com United Kingdom 4381 58
Jiangsu Heru Chemical Trading Co., Ltd. 18851404566(1497685734) 1497685734@qq.com China 75 58
Zhengzhou Acme Chemical Co., Ltd. 0371-0371-63315541 13323832564 3001332135@qq.com China 9988 58
Shanghai Haohong Pharmaceutical Co., Ltd. 400-8210725 4008210725 malulu@leyan.com China 39997 58
Bide Pharmatech Ltd. 400-1647117 15221909166 product02@bidepharm.com China 63720 58
Bide Pharmatech Ltd. 400-6005915 sales@picasso-e.com China 39668 58
Supplier Advantage
CD Chemical Group Limited 		58
Amadis Chemical Company Limited 		58
Chemipanda Bio-Tech Co., Ltd. 62
Lynnchem 58
Novachemistry 58
Jiangsu Heru Chemical Trading Co., Ltd. 58
Zhengzhou Acme Chemical Co., Ltd. 58
Shanghai Haohong Pharmaceutical Co., Ltd. 58
Bide Pharmatech Ltd. 58
Bide Pharmatech Ltd. 58
DE-7 (R)-2-chloro-1-{(2-methyloxiran-2-yl)methyl}-4-nitro-1H-imidazole 2-Chloro-1-[[(2R)-2-methyloxiranyl]methyl]-4-nitro-1H-imidazole Dilamanid intermediate 1H-Imidazole, 2-chloro-1-[[(2R)-2-methyl-2-oxiranyl]methyl]-4-nitro- 681490-93-7